40% Increase in Total + 50% Increase in Free Testosterone - Two Not Necessarily Undesirable Side Effects of Sildenafil. Human Study Confirms Direct Effect of PDE-5 Inhibition
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| Either you buy one of the bazillion OTC test-boosters that will not do anything for your testosterone levels, but may have minimal effects on your libido; or, you get a script for the blue pills and accept that one of the side-effects of these proven libido-boosters is an increase in testicular testosterone production. |
Actually you've heard Carl and me talk about the purported testosterone boosting effects of sildenafil aka Viagra on theScience Round Up in the past, but Mr. Spitzer and his colleagues from the Greenfield Health Center are the first to prove the potency of the testosterone response in male subjects who received "an optimized dose" (more on that later) of sildenafil, as well as its "direct action on the testes" in a controlled larger-scale trial (Spitzer. 2013).
More than just "spitz" (engl. "horny")
The data Matthew Spitzer et al. analyzed came from the Testosterone and Erectile Dysfunction Trial in the course of which 140 men, aged 40–70 years with erectile dysfunction, low serum total testosterone (<11.4 nmol/L; 330 ng/dL) and/or free testosterone (<173 pmol/L; 50 pg/mL) over received starting doses of
- 25mg sildenafil, if they were on an alpha-blocker
- 50mg sildenafil, if they never used sildenafil before, and
- 100mg sildenafil, if they were viagra veterans
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| Figure 1: Changes of testosterone and other hormones rel. to baseline level (Spitzer. 2013) |
The latter, i.e. the reduced luteinizing hormone levels are what actually suggests that we are dealing with a direct effect at the testicular level and not some weird hyptohalamic feedback. A centrally mediated in crease in testosterone production would after all have gone hand in hand with in- not decreases in luteinizing hormone concentration.
Minimal changes in adrenal hormones
With small, but noticeable increases in androstenedione and oestrone increased by 1.3 nmol/L (38 ng/dL; p=0.011) and 10.7 pmol/L (2.9 pg/mL; p=0.012), Spitzer et al. cannot exclude that the sildenafil induced phosphodiesterase-5 inhibition did also affect the adrenal glands - or, to be precise, "late adrenal androgen synthesis" (Spitzer. 2013):
While the exact mechanism that's responsible for the androstenedione increases must still be determined, it is, as previously mentioned, almost certain that the increase in testosterone levels was mediated by direct effects on the steroidigenic leydig cells in the testes. They are the ones that respond to the luteinizing hormone signalling from the brain have been reported to respond directly to PDE-5 inhibitors in previous studies by Andric et al. from 2007 & 2010, as well as Janjic et al. from 2012."The adrenal glands are the major site for production of androstenedione, which is converted to oestrone by aromatase. Enzyme 17,20 lyase, which converts 17a-hydroxyprogesterone to androstenedione, is upregulated with sildenafil treatment in rats.
Gingko = Brain Viagra?
This could explain the increase in serum androstenedione levels in our participants. However, an increase in 17,20-lyase activity should also result in an increase in DHEAS levels, which was not observed. Further investigation is needed to study the effect of sildenafil on adrenal androgens." (Spitzer. 2013)
More sex = more testosterone?
Whether and to which extend the increase in testosterone has also been indirectly promoted by increases in sexual activity, which have been previously reported to lead to increases in testsosterone levels after successful treatment of erectile dysfunction (Aversa. 2013) remains to be seen. The data from the study at hand does at least not support this notion, because a "greater sexual activity did not predict greater change in serum total testosterone" (Spitzer. 2013).
Other studies have associated greater sexual arousal with acute increases in LH and subsequent increases in testosterone production (LaFerla. 1978; Rowland.1987). With decreasing not increasing LH levels being one of the main findings of the study at hand, it is however more or less impossible that the increased sexual desire was the horse, not the cart in the sildenafil-related increases in testosterone levels Spitzer et al. observed in their 140 borderline to full-blown hypogonadal man.
Age-Dependent 100-300% Increase in Testosterone With 50mg of DHEA the Night Before HIIT Training. But is it Still Side Effect Free & Ergogenic When Taken Chronically?
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| Don't be fooled. DHEA won't allow you to train forever day in and day out the study at hand does yet add to previous results which already suggested that it could have its merits whenever intensity and workloads are high (learn more) |
I see, guys, I got your full attention, now! And for the ladies, ...
... who may now believe that this article wasn't for them, I have a 2008 study from Steroids, one of thejournals dealing with endocrine issues, which shows that DHEA is an important player in subcutaneous fat reduction in women (Hernandez-Morante. 2008), as well as a study in hypoadrenal women (any one suffering from the athlete's triad probably qualifies for self-induced hypoadrenalism, learn more) fromDiabetes the journal of the American diabetes association showing profound improvements in insulin sensitivity after 12-weeks on 50mg/day DHEA. So don't click this article away, thoughtlessly, ladies!
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| 5x 1 min is obviously not the only sensible HIIT protocol. Read the SuppVersity Series on Making HIIT a HIT and find out which HIIT-style would be right for you (learn more) |
This protocol was meant to shed some light unto the hitherto unknown effects of DHEA supplementation on testosterone levels during the recovery period after a bout of vigorous exercise. Interestingly, enough, you as a Suppersity addict (or soon to be addict ;-) will be aware that DHEA's beneficial effects on recovery in general have actually been proven - even in a scenario of temporary overreachig (=strategic overtaining for a short time period to elicit a maximal training stimulus; seefigure 1 and read all the details in my May 2012 article).
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| Figure 1: Changes in DHEA-S serum levels and exercise induced elevations of creatine kinase =marker of muscle damage) in 16 healthy untrained college aged men receiving 100mg/day DHEA or placebo during a 5-day "mixed-type exercise" regimen (this graph was originally discussed on May 27, 2012 and is based on Liao. 2013) |
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| Figure 2: Dehydroepiandrosterone (DHEA-S) and total testosterone levels (TT) during the interention; the asterisk (*) over the TT bars signifies significantly different from placebo in the same age group (Liu. 2013) |
"Nice, but where's the data on cortisol and what about free test & LH?"
What is not shown in figure 1 are the cortisol levels of the study participants, which were not significantly different at baseline. After the exercise intervention, the levels did yet increase significantly - irrespective of whether or not the participants were young or middle aged or received the placebo or the actual DHEA pills. Intriguingly, the drop that occured after 24h in both age groups was much more pronounced in the middle-aged guys.
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| Figure 3: Free testosterone and luteinizing hormone levels during the intervention (Liu. 2013) |
"[...] the free testosterone to cortisol [FT/C] ratio increased significantly during the training recovery for both the middle-aged and young control groups." (Liu. 2013)Now all that is good news, but what's even better news is that, at least in the short run, these profound elevations in free testosterone did not lead to lower levels of the "testosterone production trigger" luteinizig hormone (LH), which is released by your hypothalamus and tells your testes to produce more sex hormones. Now why is that important? Well, the answer is simple, a reduction in LH is not just a sign of the dreaded HTPA shut-down, it is the shutdown - or I should say the mechanistic cause of being "shut down" (=not producing any or too little sex hormones on your own).
Ok, higher T levels, lower testosterone to cortisol ratio, but what about estrogen?
A note on performance and estrogenic side-effects: An 8-week exercise intervention by Brown et al. which used 50mg DHEA /day combined with 3x total body workouts per week did not produce significant changes in any of the study parameters. Neither beneficial ones, such as greater strength increases or hypertrophy, nornegative ones such as increases in estrogen or deteriorations of the lipid profile (Brown. 1999). In 2010, on the other hand, Ostojic et al. reported that 4 weeks of 100mg DHEA, despite having no effects on the body composition of the 19-21 year-old soccer players who participated in the study, led to statistically significant increases in total testosterone (+37%), DHEA-S (+197%) and estradiol (+21% compared to the subjects in the placebo group; Ostojic. 2010). The overall significance of these results is yet questionable, since both studies were pretty underpowered (N=10 and N=20 for Brown and Ostojic, respectively). It is still noteworthy that the DHEA induced "estrogen dominance", which is one of the most frequenly heardt arguments against DHEA supplementation was not observed in either of the two studies.
If the above is the question that's just praying on your mind, then this is probably not the first article on DHEA administration you've read and what's more, the other ones were probably not published on the SuppVersity. While it is true that a handful of previous studies have in fact shown an increase of estrogen in response to the administration of DHEA, the important ratio of testosterone to estrogen was maintained even in the majority of those studies, where this effect was observed (for more details read the text in the red box on the right).Regardless of how "real" the danger of elevated estrogen levels may be, there is actually another way more important question to be answered, which pertains to the sustainability of the results. In view of the fact that the DHEA was only administered once, it is way more likely that the unquestionably beneficial effects the scientists observed could be of very transient / short-lived nature. The minimal changes in luteinizing hormone for example could well become significant (and negative) in the long run. After all a +100% increase in free testosterone is nothing your body is going to ignore for weeks. It's more likely that it will slowly bounce back to the former steady state by either reducing the production of testosterone or that of DHEA.
So even if it's unlikely that the small dosage of 50 mg would eventually shut you down, you may well lose the benefits after one months of continuous supplementation.
That being said, you could also argue that the exogenous DHEA has, just as TRT or performance enhancing drugs, the advantage of not being subject to diet-, training- and obviously age-induced reductions in their endogenous production. If any of the latter reminds of a situation / period of your life you are in, your chances of seeing benefits would at least be higher - whether they would be high enough to actually manifest in beneficial training outcomes remains questionable, though.
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| It is unfortunate that science gave up on DHEA, when it became clear that it's not the fountain of youth. I mean, greater fat-inhibition effects than testosterone are nice, no (learn moreabout those)? |
Unfortunately, the evidence from these short-term interventions does not tell us anything about the beneficial and detrimental effect the low and high dose protocols from the Liu and the Liaostudies will have. Personally I would assume that the benefits will wane off, but in the absence of corresponding studies, this is mere guesswork. After all, 99% of the previous research on DHEA has been done in sedentary old men and women. Few trials investigated the effects on young or middle aged subjects and less than a handful did that in an exercise scenario with any resemblances to yours or mine.
So there is probably need for at least another SuppVersityarticle (obviously based on a novel study), before you will hear me recommend the use of DHEA as an ergogenic supplement. Now, if you want to make sure, you don't miss that, I suggest you start following the SuppVersity on Facebook, Twitter or simply with your favorite RSS reader (click here to get to the channel ;-)
New Study Says: Boron Does Indeed Raise Free Testosterone
There have been rumors on the Internet for quite some time - "Did you hear? Boron increases testosterone!" Hitherto, however, these claims have not been substantiated by reliable scientific research. A recent study done by a group of scientists from Iran (Naghii. 2010) yet seems to prove that this is more than the steroid-loaden phantasy of an average gymrat.
In a placebo controlled study, the scientists found that supplementation with 10mg Boron/day did not only lower SHGB and thus raise testosterone, it did also lower three inflammatory biomarkers(Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and tumor necrosis factor-alpha (TNF-α)):
As you can see in table 1, the testosterone to estrogen ratio more than doubled (0.31 to 0.67). This alone makes me believe that it won't take too long for supp companies to notice this little trace mineral and to include it in more and more of their products. Hitherto it is already found in some formulations, like multi-vitamins, meal replacements and other stuff that is enriched with minerals the dosages, however, are minuscule and far from the 10mg used in the present study.
The scientists also investigated the time-course of the effect of boron supplementation on day 1 of the study and interestingly it took only 6 hours for free testosterone to rise from 8.55pg/ml to 11.25pg/ml. To me, this suggests that there is more to boron supplementation than just repleting exhausted blood and/or tissue levels.
Update: I have been digging a little into the possible mechanism of action behind the increase in testosterone and my personal take it that boron is a (weak) anti-estrogen. By cutting estrogen by 50% (cf. table 1) your body will automatically reduce SHGB, which is up-regulated by estrogen. This frees testosterone and may in fact provide (minor) benefits in muscle gain, libido & fat loss. I suspect that in the end this could be related to a reduction in manganese and an increase in magnesium & calcium retention (cf. Acu-Cell information about boron) that follows the administration of large amounts of boron. These is highly speculative and may only be part of the picture, though.
Also, in view of conflicting evidence from previous studies (e.g. Nagghi. 2006), which found that supplemental boron increased (not decreased) estrogen in men, further investigations are warranted.
In a placebo controlled study, the scientists found that supplementation with 10mg Boron/day did not only lower SHGB and thus raise testosterone, it did also lower three inflammatory biomarkers(Interleukin-6 (IL-6), high sensitive CRP (hsCRP) and tumor necrosis factor-alpha (TNF-α)):
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| Table1: Hormones and inflammatory biomarkers concentration (mean ± SD) plus hormone ratios following consumption of placebo (day 0) and weekly boron supplementation (day 7) |
The scientists also investigated the time-course of the effect of boron supplementation on day 1 of the study and interestingly it took only 6 hours for free testosterone to rise from 8.55pg/ml to 11.25pg/ml. To me, this suggests that there is more to boron supplementation than just repleting exhausted blood and/or tissue levels.
Update: I have been digging a little into the possible mechanism of action behind the increase in testosterone and my personal take it that boron is a (weak) anti-estrogen. By cutting estrogen by 50% (cf. table 1) your body will automatically reduce SHGB, which is up-regulated by estrogen. This frees testosterone and may in fact provide (minor) benefits in muscle gain, libido & fat loss. I suspect that in the end this could be related to a reduction in manganese and an increase in magnesium & calcium retention (cf. Acu-Cell information about boron) that follows the administration of large amounts of boron. These is highly speculative and may only be part of the picture, though.
Also, in view of conflicting evidence from previous studies (e.g. Nagghi. 2006), which found that supplemental boron increased (not decreased) estrogen in men, further investigations are warranted.
Free testosterone (FT) is an essential element involved in the overall health in men. This vital hormone is responsible for the transition into puberty a boy, and finally into manhood. There are studies that free testosterone levels to announce influence functions and bodybuilding potential neurological problems, reproductive. Free testosterone refers to testosterone circulating in the blood stream and ready repair tissue.
FT is considered to be biologically active meaning that it is prepared to enter into a cell and to operate as a receptor. A whopping 98 percent of testosterone is bound by a protein called albumin and sex hormone binding globulin (SHBG).
Sex Hormone Binding Globulin (SHBG)SHBG is produced primarily in the liver, released into the bloodstream. SHBG is also produced in the brain and testes of the male. The bioavailability (the ability to create FT) of testosterone influenced by SHBG. The decrease in SHBG caused an increase in FT. SHBG levels are reduced by the use of anabolic steroids (drugs that mimic testosterone).
Free testosterone deficiencyA deficiency in the FT levels in the male is significantly impeded the ability to build muscle fast. When SHBG has the testosterone is bound, it is not for the free testosterone in the blood can circulate. In its free state, testosterone is able to tilt the growth of muscle mass. Defects in this meant testosterone levels were conducted with a variety of factors to disturb clinical trials.
Apart from prohibiting the rapid growth of muscle mass, a study suggests May 2007 made that defects will be attributed to free testosterone levels in premature coronary heart disease. The deficiency in these planes is also thought to ascribe the contraction of the metabolic syndrome and even type 2 diabetes.
Increasing free testosteroneIf you want more testosterone, it is necessary to decrease SHBG levels in the body. The bioavailability of your testosterone may be achieved by the introduction of anabolic steroids in the body. While synthetic anabolic steroids have a negative stigma that this is mainly due to abuse of this substance, and the potentially harmful side effects of synthetic form of anabolic steroids.
Steroids are organic compounds that act like testosterone. Instead, take the synthetic form of testosterone (anabolic steroids), it is better to let your body more free testosterone with testosterone produced naturally occurring dietary supplements produce. Among the strongest of these is Deer Antler Velvet. Deer Antler Velvet has been clinically tested all over the world, and the results show that this supplement not only increases the free testosterone levels in the blood moving, but also connected to a rapid growth of muscle mass.
The Professional Baseball Commission has restricted the use of Deer Velvet Antler, due to its performance-enhancing properties. While the FDA does not approve of natural supplements like Deer Antler Velvet, researchers worldwide have convincing evidence of the natural steroid properties of this supplement. Not to mention Chinese doctors have used for 2,000 years Deer Antler Velvet.
The use of natural supplements, such as the called of InnerJetix Laboratories Formula Alpha combines times-what to support deer antler with a variety of other natural rain forest herbs that will balance the effects of deer antler improvement in the growth of this form of testosterone, thereby the ability of the body to build muscle fast naturally.
AndroNox – Healthy Testosterone Booster Supplement?
http://supplementpolice.com/andronox/
Every now and then, your body needs a boost of vital compounds to keep you going. Eating a healthy diet and performing your regular workout regimen are just not enough. To truly build the ripped and powerful physique that you are striving for, you need a supplement that enhances your testosterone levels.
The issue is, not all testosterone supplements are effective or made with quality ingredients.
To truly realize results, you need a product that you can count on.
Luckily, this review has you covered by introducing AndroNox. This testosterone booster has helped countless bodybuilders, athletes, and everyday men build a strong and powerful body.
The supplement is compatible with a regular workout regimen and healthy diet as well. Here is everything you need to know about AndroNox so that you can make the right decisions for your routine.
What is AndroNox?
AndroNox is a dietary supplement that naturally enhances your testosterone levels. The supplement features an array of effective ingredients that stimulate the adrenal glands and male testes so that they produce an effective amount of testosterone.
With higher testosterone levels, you will experience a number of improvements in your workout routine, your body mass, and even your sex life as well.
AndroNox is relatively new on the market, but thus far, it has received positive feedback from users.
If you are ready to improve the quality of your workout routine and your performance, AndroNox has you covered.
The Science Behind AndroNox
When choosing a testosterone booster, it is of upmost importance to opt for one that you can count on and whose benefits are supported through clinical research, studies, and trials.
In this case, AndroNox has undergone vigorous testing, which has enabled the product’s producers to provide you with the next generation of testosterone supplements.
Here, the science behind the supplement has to do with its ability to naturally increase your body’s testosterone levels.
Dissimilar to other testosterone enhancers that simply flood your body with synthetic testosterone, this one features a number of ingredients that reach your testes and adrenal glands.
Once the ingredients reach these areas, they cause the body to produce more testosterone.
This increases the amount of free testosterone in your body, which then triggers a number of processes that are conductive toward a stronger, larger, leaner, and ripped body.
Keep in mind that to experience the full effects of this supplement, it is necessary to take it on a daily basis and as instructed. Moreover, you must combine it with a normal workout routine and a healthy diet.
What to Expect
There are a number of great advantages associated with AndroNox. It is also paired with the JuggerNox product which is help to increase your workout energy and nitric oxide blood flow. For example, when you incorporate this supplement into your daily workout routine, here are the main benefits that you can expect to experience:
- Promotes Anabolic Activity
Anabolic activity is necessary for muscle growth. This activity is associated with the increase of anabolic enzymes in the body.
For those who are unaware, anabolic enzymes are substances that convert to complex compounds, which include bone and muscle tissues. As you hit the gym, your body becomes overwhelmed from the workout.
Fortunately, since this supplement promotes anabolic activity, it ensures that you have enough energy to maintain muscle repair and continued activity after your workout.
- Increases Stamina Levels
You can also expect to see an increase in stamina levels. The higher stamina takes place during and well after your workout. Better yet, you will not need to deal with the uncomfortable crash frequently associated with caffeine and other substances. Instead, this supplement takes you back to your former energy levels.
- Supports Muscle Growth
AndroNox also supports muscle growth by enhancing your performance at the gym. You will be able to lift heavier and larger weights more easily and longer. In turn, this promotes the breakdown of muscle mass and increases your recovery time. This way, you will be prepared for your next workout at the gym.
- Improves Mental Focus
Finally, the supplement also enhances your mental focus. This way, you will be able to push through your workout or any other tasks at hand afterwards. The enhanced mental focus lasts you for hours on end and it does not lead to a wear down in energy levels or otherwise.
As you can tell, there are a number of advantages associated with Andro Nox. With this supplement, you can finally realize your body building goals.
Ingredients Inside AndroNox
The formula features a number of great ingredients that you can count on for high-quality performance and results. For instance, Andro Nox, features the following key ingredients to help you attain massive muscle growth and higher energy levels:
Horny Goat Weed
Horny Goat Weed is a herb that stimulates the adrenal gland and testes to stimulate more testosterone. The substance continues to work for hours on end so that your testosterone remains high and stable.
Tongkat Ali
Tongkat Ali is a common testosterone booster found in testosterone enhancing supplements. It also is known to increase your libido, sex drive, and stamina.
Maca Root
Maca Root is a testosterone enhancer that also blocks the body’s production of estrogen. With this ingredient, you can maintain stable levels of testosterone for optimal performance.
Creatine
The final key ingredient is creatine and it improves athletic performance. With this ingredient, you’ll be able to push yourself better at the gym by lifting more and prolonging your workout time. In addition, the ingredient also aids in muscle recovery after your workout so that you’ll be prepared for your next routine.
Free Trial
If you are interested in AndroNox, then you can purchase the product through the brand’s website. Currently, the brand is offering a promotion where you can try a trial product for 14 days for free. If you keep the product past the 14 day period, you allow the brand to charge you for the regular product and to enroll you in a monthly subscription service.
Summary
Overall, AndroNox is a high-quality and effective testosterone booster. With this supplement, you can develop the strong, powerful, and ripped physique that you’ve always wanted. To get started with AndroNox, visit the brand’s website today. Do not forget to read the terms and conditions as well.
About Testosterone Products for Women
The supplement world is filled with products that promise muscle gain, extra energy, and accelerated weight loss.
Out of all of the different supplements targeted towards increased workout results, testosterone boosters have certainly gained major ground in the field. Because of certain stigma attached to testosterone, the majority of its users are male while females tend to avoid it.
This testosterone booster avoidance is usually due to thoughts of developing androgenic side-effects, which of course isn’t desired by most females.
However, most of these fears are based on a lack of knowledge of how testosterone interacts with the female physiology.
Testosterone is one of two anabolic hormones found in the body (the other one is growth hormone).
Both of these hormones play a major role in strength gain, muscle hypertrophy, and muscle leanness.
Naturally, females have less testosterone in their bodies than males do. They have less free testosterone than males do, as well.
On average, it is estimated that females only have about 10% the amount of testosterone in their bodies that males have. This number is rather simplified but is a good way to understand the differences between male and female testosterone levels.
It has been determined in the science field that testosterone does help with muscle gain and increase in strength.
It has also been proven that you don’t have to have an increased level of testosterone in your body in order to see development in muscles and strength.
Essentially what this means is that you can get to your final desired muscle and strength levels without the help of testosterone, but you can also do it a bit easier if you employ the use of testosterone to help you along the way.
Some women have reported amazing results after taking testosterone. Better and deeper sleep is one of the benefits of taking testosterone boosters, which is absolutely vital for your body.
Rest is just as important for your body as working out, and without proper rest, you will not have the energy to do all the necessary things needed to get your muscle weight and strength to the right levels.
Another benefit of increased testosterone is clearer skin. You would be amazed how smooth and acne free your skin will become once you start taking testosterone boosters. If you have an issue with irregular and long menstrual cycles, testosterone can help regulate and shorten your cycles.
This can be a huge help for some women. Energy levels also share a direct relationship with testosterone levels in women. It isn’t uncommon to see the increased levels of energy in women who have been taking testosterone boosters, both at the gym and throughout their regular daily lives.
One other benefit to an increased testosterone level which many people overlook is how much less bruising occurs on your body if you are taking testosterone supplements.
Because of the way testosterone works on your physiology and how it affects your muscles, bruising is severely reduced when small bumps or increased muscle loads occur.
There are plenty of other benefits to taking testosterone boosters. The above are only a few that were reported by women who have seen these changes first hand while at the gym or just in their daily routine.
There is another little side note that women should consider. As you age, your testosterone levels naturally decrease.
This can cause some adverse side-effects. Obviously, the number one side-effect of reduced testosterone levels is loss in muscle weight.
While this isn’t necessarily a bad thing and generally is considered to be a normal thing for all aging people, it can be slowed down and reduced.
If you are noticing muscle mass loss as you get older, it might be a good idea for your doctor to check your testosterone levels to make sure they haven’t dropped below normal. If they have, then perhaps taking a testosterone booster is a good idea.
The other side-effect that can be rather troublesome for some women is decreased sex drive.
This is a topic that a lot of people tend to avoid because of embarrassment or discomfort when talking about it with anyone, including your doctor, but we think that this topic should never be avoided.
If you are seeing reduced libido levels, then you should definitely mention it to your doctor. Simply taking some testosterone supplements could get you back on track with your sex drive, which can produce some positive results both short-term and in the long run.
There are hundreds, if not thousands, of reasons why you might decide to take testosterone boosters.
We always suggest that you discuss those reasons with a medical professional. Most of the time, they will do a simple blood test to determine if you can benefit from testosterone supplements.
Even if your testosterone levels are normal and you are looking to gain a boost needed for your workouts to increase our muscle mass and body strength, you should still mention this to your doctor. T
hey will be able to give you some suggestions or recommendations regarding your situations. Your doctor knows best what is more suitable for your body, and they have your full medical history which can help in deciding what levels of testosterone you should take or if there might be any adverse effects to you taking testosterone boosters.
Let’s say that after countless hours of research and consultations with your doctor, you have decided to start taking testosterone supplements or boosters.
Where do you go from here? One of the hardest decisions that you have to make once you determine that testosterone boosters are what you need is making the right choice between the hundreds of different testosterone products out there.
While the market is saturated with male testosterone supplements, there aren’t many specific testosterone boosters for women.
What this means is that you need to choose the best testosterone supplement out there and determine the right dosage for you.
This can be tricky, and it is always suggested that you talk to your medical professional to determine what dosages are right for you.
Since testosterone isn’t the primary hormone in women, it is very important to get the right levels of this hormone, otherwise, you might see some adverse side-effects.
We have compiled a list of best-known testosterone boosters and supplements. These products are known for their effectiveness and the results that they produce.
Both women and men have commented on how effective each of these products can be and showed positive feedback.
Be very careful when taking these products and make sure you follow the suggested dosage for whichever sex you are. There should be directions for both men and women, so please do not confuse the two.
ZMA JYM
“ZMA Capsule to Help Maintain Optimal Hormone Levels.”“Designed to Maximize Muscle Strength and Support Recovery.”
This product isn’t directly designed to boost your testosterone. Instead, it’s more about helping to maintain the correct levels of hormones via the use of other minerals and vitamins.
This is the perfect product for those who have reduced levels of testosterone and simply need to balance their levels back up to normal.
There have been many reviews which point to great results when using this specific supplement.
Some reviewers have mentioned that the deep sleep effect which you can usually get from some other supplements isn’t as prominent in this product.
So those of you who don’t necessarily need optimal sleep and can function without a problem without that deep, dark sleep that everyone is talking about will find that this product is perfect.
Either way, the combination of multiple nutrients, vitamins, and minerals is still very beneficial for both males and females. They will certainly have an excellent effect on your testosterone levels.
True GRIT Test Booster
“Scientifically Dosed Test Booster Tablets.”“Designed To Support Free Testosterone And Estradiol Balance.”
The idea behind this supplement is to combine the best nutrients possible to increase your testosterone levels naturally.
The formula is designed to increase both free and total testosterone levels. The company responsible for this product has stated that they used clinical studies key ingredients which have been proven to increase testosterone levels while maintaining the right levels without going beyond the healthy level range.
Many reviewers stated that they are seeing improvements in strength levels as well as energy, but the effect is produced over time rather than seeing instant and immediate results.
This does make sense since the nutrients used in this product are all natural and work a bit slower with your body rather than synthetic or direct testosterone injections.
We think this is small price to pay when in return you are much safer with the levels and won’t exceed the safe levels of testosterone in your body.
TESTOBOOST Testosterone Booster Supplement
“Lose extra fat, gain muscle mass & break training plateaus.”“20x MORE POWERFUL to enhance Test levels post-workout.”
TestoBoost is one of the most bought products online. It has gained a lot of ground in the testosterone boosting industry.
The product makers are promising that you will get leaner muscle, stabilized testosterone production, dramatically increased libido, and increased mental focus and clarity.
Their ingredients have been meticulously tested and formulated by doctors, as well as tested for purity, potency, and consistency.
The majority of reviewers left positive feedback with statements pointing to the excellent effectiveness of this product and its ability to produce amazing results.
Almost all positive reviews stated that while working out the person had plenty of energy and was able to finish their workout without major fatigue levels.
The only thing that we suggest is to talk to your doctor in order to determine the correct dosage that you should take if you are a female.
It seems that this product is primarily targeted towards men and doesn’t have a recommended dosage level for women.
UltraTest Natural Testosterone Booster Supplement for Men and Women
“Contains only natural ingredients derived from plants, herbs, minerals, and vitamins.”“Supports your body’s athletic performance with synergistic clean energy ingredients.”
It seems that the main focus of UltraTest is their use of natural ingredients derived from plants, herbs, minerals, and vitamins.
The company suggests this product for those who have a lack of stamina, low sex drive, need more power in the gym or in the bedroom, or are looking to gain muscles while losing weight.
One reviewer stated that they were worried about possible side-effects of this product since they were a female, but so far they have not seen any adverse effects.
Furthermore, they stated that there has been a major improvement in their muscle retention as well as an increased ability to do more at the gym.
Many others said that they were happy with the results and benefits that this product has to offer.
The suggested dosage for this product is three capsules before bedtime, which was derived as the optimal recommended dose as suggested by experts.
We still think you should consult your medical professional to determine if this is the correct dose to take if you are a female.
Testosterone Products for Women Review Summary
The above are only four of all the available products on the market. While we do think these are best choices out there, you have to keep in mind that each body is different and unique in their own way.
We determined these products to be the most effective depending on the ingredients used and the reviews written about each product. By no means does this determine that the product will be perfect for you as well.
It is often hard to find out what will work for you and what will not. The best way to approach this dilemma is to try the product and see how you feel after a week or two. Remember to maintain a proper diet as well as a proper exercise routine.
Sitting on a couch and eating testosterone booster isn’t going to give you the best results possible.
In fact, this might be very harmful to your body. You need to move and exercise. You need to spend that extra energy somewhere. Otherwise, the overabundance of this energy can be troublesome.
Make sure you are well informed and have some knowledge when dealing with testosterone boosters.
Diving in and experimenting isn’t the best choice unless you have done your research first. Doing so blindly is definitely not a good idea.
About Testosterone Products for Women
The supplement world is filled with products that promise muscle gain, extra energy, and accelerated weight loss.
Out of all of the different supplements targeted towards increased workout results, testosterone boosters have certainly gained major ground in the field. Because of certain stigma attached to testosterone, the majority of its users are male while females tend to avoid it.
This testosterone booster avoidance is usually due to thoughts of developing androgenic side-effects, which of course isn’t desired by most females.
However, most of these fears are based on a lack of knowledge of how testosterone interacts with the female physiology.
Testosterone is one of two anabolic hormones found in the body (the other one is growth hormone).
Both of these hormones play a major role in strength gain, muscle hypertrophy, and muscle leanness.
Naturally, females have less testosterone in their bodies than males do. They have less free testosterone than males do, as well.
On average, it is estimated that females only have about 10% the amount of testosterone in their bodies that males have. This number is rather simplified but is a good way to understand the differences between male and female testosterone levels.
It has been determined in the science field that testosterone does help with muscle gain and increase in strength.
It has also been proven that you don’t have to have an increased level of testosterone in your body in order to see development in muscles and strength.
Essentially what this means is that you can get to your final desired muscle and strength levels without the help of testosterone, but you can also do it a bit easier if you employ the use of testosterone to help you along the way.
Some women have reported amazing results after taking testosterone. Better and deeper sleep is one of the benefits of taking testosterone boosters, which is absolutely vital for your body.
Rest is just as important for your body as working out, and without proper rest, you will not have the energy to do all the necessary things needed to get your muscle weight and strength to the right levels.
Another benefit of increased testosterone is clearer skin. You would be amazed how smooth and acne free your skin will become once you start taking testosterone boosters. If you have an issue with irregular and long menstrual cycles, testosterone can help regulate and shorten your cycles.
This can be a huge help for some women. Energy levels also share a direct relationship with testosterone levels in women. It isn’t uncommon to see the increased levels of energy in women who have been taking testosterone boosters, both at the gym and throughout their regular daily lives.
One other benefit to an increased testosterone level which many people overlook is how much less bruising occurs on your body if you are taking testosterone supplements.
Because of the way testosterone works on your physiology and how it affects your muscles, bruising is severely reduced when small bumps or increased muscle loads occur.
There are plenty of other benefits to taking testosterone boosters. The above are only a few that were reported by women who have seen these changes first hand while at the gym or just in their daily routine.
There is another little side note that women should consider. As you age, your testosterone levels naturally decrease.
This can cause some adverse side-effects. Obviously, the number one side-effect of reduced testosterone levels is loss in muscle weight.
While this isn’t necessarily a bad thing and generally is considered to be a normal thing for all aging people, it can be slowed down and reduced.
If you are noticing muscle mass loss as you get older, it might be a good idea for your doctor to check your testosterone levels to make sure they haven’t dropped below normal. If they have, then perhaps taking a testosterone booster is a good idea.
The other side-effect that can be rather troublesome for some women is decreased sex drive.
This is a topic that a lot of people tend to avoid because of embarrassment or discomfort when talking about it with anyone, including your doctor, but we think that this topic should never be avoided.
If you are seeing reduced libido levels, then you should definitely mention it to your doctor. Simply taking some testosterone supplements could get you back on track with your sex drive, which can produce some positive results both short-term and in the long run.
There are hundreds, if not thousands, of reasons why you might decide to take testosterone boosters.
We always suggest that you discuss those reasons with a medical professional. Most of the time, they will do a simple blood test to determine if you can benefit from testosterone supplements.
Even if your testosterone levels are normal and you are looking to gain a boost needed for your workouts to increase our muscle mass and body strength, you should still mention this to your doctor. T
hey will be able to give you some suggestions or recommendations regarding your situations. Your doctor knows best what is more suitable for your body, and they have your full medical history which can help in deciding what levels of testosterone you should take or if there might be any adverse effects to you taking testosterone boosters.
Let’s say that after countless hours of research and consultations with your doctor, you have decided to start taking testosterone supplements or boosters.
Where do you go from here? One of the hardest decisions that you have to make once you determine that testosterone boosters are what you need is making the right choice between the hundreds of different testosterone products out there.
While the market is saturated with male testosterone supplements, there aren’t many specific testosterone boosters for women.
What this means is that you need to choose the best testosterone supplement out there and determine the right dosage for you.
This can be tricky, and it is always suggested that you talk to your medical professional to determine what dosages are right for you.
Since testosterone isn’t the primary hormone in women, it is very important to get the right levels of this hormone, otherwise, you might see some adverse side-effects.
We have compiled a list of best-known testosterone boosters and supplements. These products are known for their effectiveness and the results that they produce.
Both women and men have commented on how effective each of these products can be and showed positive feedback.
Be very careful when taking these products and make sure you follow the suggested dosage for whichever sex you are. There should be directions for both men and women, so please do not confuse the two.
ZMA JYM
“ZMA Capsule to Help Maintain Optimal Hormone Levels.”“Designed to Maximize Muscle Strength and Support Recovery.”
This product isn’t directly designed to boost your testosterone. Instead, it’s more about helping to maintain the correct levels of hormones via the use of other minerals and vitamins.
This is the perfect product for those who have reduced levels of testosterone and simply need to balance their levels back up to normal.
There have been many reviews which point to great results when using this specific supplement.
Some reviewers have mentioned that the deep sleep effect which you can usually get from some other supplements isn’t as prominent in this product.
So those of you who don’t necessarily need optimal sleep and can function without a problem without that deep, dark sleep that everyone is talking about will find that this product is perfect.
Either way, the combination of multiple nutrients, vitamins, and minerals is still very beneficial for both males and females. They will certainly have an excellent effect on your testosterone levels.
True GRIT Test Booster
“Scientifically Dosed Test Booster Tablets.”“Designed To Support Free Testosterone And Estradiol Balance.”
The idea behind this supplement is to combine the best nutrients possible to increase your testosterone levels naturally.
The formula is designed to increase both free and total testosterone levels. The company responsible for this product has stated that they used clinical studies key ingredients which have been proven to increase testosterone levels while maintaining the right levels without going beyond the healthy level range.
Many reviewers stated that they are seeing improvements in strength levels as well as energy, but the effect is produced over time rather than seeing instant and immediate results.
This does make sense since the nutrients used in this product are all natural and work a bit slower with your body rather than synthetic or direct testosterone injections.
We think this is small price to pay when in return you are much safer with the levels and won’t exceed the safe levels of testosterone in your body.
TESTOBOOST Testosterone Booster Supplement
“Lose extra fat, gain muscle mass & break training plateaus.”“20x MORE POWERFUL to enhance Test levels post-workout.”
TestoBoost is one of the most bought products online. It has gained a lot of ground in the testosterone boosting industry.
The product makers are promising that you will get leaner muscle, stabilized testosterone production, dramatically increased libido, and increased mental focus and clarity.
Their ingredients have been meticulously tested and formulated by doctors, as well as tested for purity, potency, and consistency.
The majority of reviewers left positive feedback with statements pointing to the excellent effectiveness of this product and its ability to produce amazing results.
Almost all positive reviews stated that while working out the person had plenty of energy and was able to finish their workout without major fatigue levels.
The only thing that we suggest is to talk to your doctor in order to determine the correct dosage that you should take if you are a female.
It seems that this product is primarily targeted towards men and doesn’t have a recommended dosage level for women.
UltraTest Natural Testosterone Booster Supplement for Men and Women
“Contains only natural ingredients derived from plants, herbs, minerals, and vitamins.”“Supports your body’s athletic performance with synergistic clean energy ingredients.”
It seems that the main focus of UltraTest is their use of natural ingredients derived from plants, herbs, minerals, and vitamins.
The company suggests this product for those who have a lack of stamina, low sex drive, need more power in the gym or in the bedroom, or are looking to gain muscles while losing weight.
One reviewer stated that they were worried about possible side-effects of this product since they were a female, but so far they have not seen any adverse effects.
Furthermore, they stated that there has been a major improvement in their muscle retention as well as an increased ability to do more at the gym.
Many others said that they were happy with the results and benefits that this product has to offer.
The suggested dosage for this product is three capsules before bedtime, which was derived as the optimal recommended dose as suggested by experts.
We still think you should consult your medical professional to determine if this is the correct dose to take if you are a female.
Testosterone Products for Women Review Summary
The above are only four of all the available products on the market. While we do think these are best choices out there, you have to keep in mind that each body is different and unique in their own way.
We determined these products to be the most effective depending on the ingredients used and the reviews written about each product. By no means does this determine that the product will be perfect for you as well.
It is often hard to find out what will work for you and what will not. The best way to approach this dilemma is to try the product and see how you feel after a week or two. Remember to maintain a proper diet as well as a proper exercise routine.
Sitting on a couch and eating testosterone booster isn’t going to give you the best results possible.
In fact, this might be very harmful to your body. You need to move and exercise. You need to spend that extra energy somewhere. Otherwise, the overabundance of this energy can be troublesome.
Make sure you are well informed and have some knowledge when dealing with testosterone boosters.
Diving in and experimenting isn’t the best choice unless you have done your research first. Doing so blindly is definitely not a good idea.
Vitaligenix T10 – Testosterone Booster For Male Vitality?
https://supplementpolice.com/vitaligenix-t10/
You would not have to be a diligent student of theSuppVersity to know: Coffee is a truly remarkable brew. Even mainstream media has gotten wind of the multitude of beneficial effects a moderate intake of the former drink of the kings and popes can have on your health and if it was not for the authors and newscasters blind reliance on whatever the press release guys are telling them, it would probably not even have been necessary for me to broach the beneficial effects coffee can have on your metabolic health and overall well-being in posts like "Coffee - 3 Cups a Day Keep Insulin at Bay", "Pre-Workout Caffeine: Fat Liberator, Substrate Modulator, Trans-Fatty Acid Eliminator & Performance Upregulator!" and many more.
So what is it this time? What else can coffee do for you?
I guess something only few people others than SuppVersity readers will be aware of is the fact that caffeine and therefore coffee makes a nice testosterone booster (Beavon. 2008; study was discussed briefly as part of a longer post on June 20, 2012 an mentioned previous times in other posts) -- at least if you stick to moderate doses of ~300-400 mg before a workout. So, unless you are a newbie or missed the respective news, you should not be surprised that a recent study from the Harvard School of Public Health (Wedick. 2012), which had actually been designed mainly to investigate the effects of 5x 6-ounze cups caffeinated and decaffeinated coffee (both instant coffees; brand: NestlĂ©’s Taster’s Choice) on serum levels of sex hormone-binding globulin (SHBG), found that the consumption of both 'real' and 'fake' (=decaffeinated) instant coffee did lead to increases in total and free testosterone and profound decreases in estradiol (bound and free).
As the data in figure 1 goes to show these changes were unfortunately transient and the impressive +189% increase in the testosterone to estrogen ratio which occurred during the first month of treatment totally disappeared within the next four weeks. On the other hand, the effects on SHBG the scientists had expected based on the assumption that both SHBG and caffeine intake have been found to be associated with lower risk of type II diabetes in large epidemiological studies, was non-existent in the first and second 4 weeks of the study... at least in the male subjects who were all overweight, nonsmokers and habitually coffee consumers, who had been required to abstain from caffeine intake for at least 2 weeks before the study was conducted.
If you take a look at the data from the female participants (likewise overweight non-smokers, habitual caffeine consumers and, at the beginning of the study, 'dried out'; see figure 2), a different image emerges, in the women we do in fact see a transient rise in SHBG, which goes hand in hand with a decrease in testosterone, de to which the T/E ratio drops by -36% and -54% in the groups drinking caffeinated and noncaffeinated coffee respectively. Just as in their male counterparts, the levels did go back up in the second part of the study so that all values, including the SHBG levels were back in to normal after 8 weeks (please note changes in the 20% range are irrelevant and could be due to having a meal before the test, bad sleep, whatever).
The relative data tells only part of the story
If we do now take a closer look at the actual data and discard the comparison to the control group the scientists the picture becomes even more complex. After all the data in figure 4clearly indicates that we are dealing with a combined effect here. It is correct that the ingestion of the caffeinated beverage had pronounced effects on the T/E ratio especially in the male participants, what the data in figure 1 does yet not tell you is the fact that this effect was also so pronounced, because simply stopping to drink caffeine reduced the T/E ratio from 18.1 to 8.4, i.e. by 54%(!).
Now this certainly reduces the effect size, but it does not totally negate the effect. After all the 'real' coffee drinkers (w/ caffeine) did still increase their T/E ratio from 16.2 to 24.2 -- a certainly likewise noteworthy increase of +29% that is however still far away from the exorbitant +189% increase compared to the poor guys who did not just lose their coffee, but also their virility.
So what does this tell use?
Regardless of whether you stop or start drinking coffeine, the endocrine "disturbances" are relatively short-lived and only further testimony to the fact that our bodies will always try to find a new "steady state" in what they consider normal.
Bottom line: There are a myriad of good reasons to drink coffee, getting more manly or more feminine is yet not one of them. Disappointed? Well, on the other hand this means coffee is no endocrine disruptor - and at least in this overweight population it seems to have a marginally beneficial baseline effects (thus the detrimental effects of abstinence).
Most men agree that they want to be strong and virile, even if that looks a bit different for every man. This need comes from an almost biological urge in the male mind, one that feels like, even though society has changed, men still need to be strong enough to protect their loved ones. Thankfully, the male body was built to be strong, with every aspect of the male form framed around power and strength.
In order for men to get the strength and power they want in their bodies, testosterone is a vital ingredient. Testosterone has long been referred to as the ‘male’ hormone and it plays a huge role in muscle building, strength, and general vitality in men. The hormone provides men with the focus and drive they need to build their muscle mass and strength, all while helping them make better gains every time they step foot in the gym.
Unfortunately, men don’t have an endless supply of testosterone, which is why it’s so important for men to find a supplement formulation that helps keep their testosterone at healthy levels. For those who have committed their lives to building the ideal body or those who are ready to start out on their health and wellness journey, having a dedicated testosterone support supplement is critically important. With these supplements, men will be able to push themselves to the limit, getting better results in shorter time.
The problem with the majority of testosterone supplements is that they are either completely ineffectual or they don’t contain enough of the ingredients they claim to have to be beneficial. However, for those who are ready to boost their testosterone levels with a superior product, there is Vitaligenix T10. This testosterone boosting supplement is able to give men all the strength and vitality they need to get the best results imaginable when it comes to muscle growth and strength.
What Is Vitaligenix T10?
Vitaligenix T10 is a testosterone boosting supplement formulated and manufactured by MuscleTech. Coming in the form of a liquid plasma capsule, Vitaligenix T10 was crafted based on years of intense research and study. While this time took effort and money, the end results were more than enough to make up for the hard work. Now Vitaligenix T10 is one of the most advanced, unique formulas available on the market to boost testosterone levels in men.
While there are several different types of testosterone formulas, Vitaligenix T10 is unique in that it was made specifically for active, athletic men. Because men who are already committed to building their bodies think and work fast, Vitaligenix T10 was designed to increase testosterone levels just as fast. Now, users can get a testosterone boost that will be obvious within ten hours of first taking Vitaligenix T10.
MuscleTech, the creators of Vitaligenix T10, keep to their strict manufacturing and formulating standards with this testosterone boosting supplement. With Vitaligenix T10, users can have peace of mind that they’re getting the best support and the best results from one, easy to take, effective supplement.
Importance of Free Testosterone
To have a better idea of why Vitaligenix T10 is such an important supplement, especially for those who are moving towards meeting their health and fitness goals, a better understanding of how testosterone works in the male body is needed.
As mentioned above, testosterone is one of the defining hormones available in the male body. Testosterone is responsible for the drive, focus, energy, strength, and muscle mass found in men. The problem with testosterone is that it doesn’t last forever. In fact, while many men think they won’t have to worry about decreasing testosterone levelsuntil their wrinkled and grey, levels actually start decreasing in men around the age of 25 or 30. After this decrease starts, men will lose about 1% of their testosterone every year.
The good news for men is that there are actually two types of testosterone in the body. The first form of testosterone is the testosterone that is already bound to sex hormone-binding globulin (SHBG). Because this testosterone is already bound, it is the testosterone used by the body. However, there is another form of testosterone called free testosterone that is not bound to SHBG, existing outside of the testosterone burning process.
Because free testosterone isn’t bound to SHBG, it isn’t utilized by the body. However, when the right circumstances are created, this testosterone can be accessed by men, giving them the boost they need to perform better. Vitaligenix T10 works by releasing the free testosterone in men, so the body is better able to absorb it and use it in the same way bound testosterone is used.
Benefits of Vitaligenix T10
The number one benefit of Vitaligenix T10 is that it is crafted using the finest natural ingredients. In fact, the key ingredients used to formulate Vitaligenix T10 are all backed by research and multiple scientific studies. Vitaligenix T10 put just as much time crafting this supplement as many labs put into creating medications. And since many testosterone enhancers aren’t based on any research, this is also a point that separates Vitaligenix T10 from other options on the market.
Vitaligenix T10 was created to be as comprehensive a formulation as possible. By working to support the multiple aspects of the testosterone boosting process, Vitaligenix T10 is able to give better results than other options currently available. Because the ingredients used in Vitaligenix T10 were specifically chosen to support the overall health and wellness of users, it is able to boost testosterone levels while also decreasing estradiol levels.
In addition to offering better results, Vitaligenix T10 is able to offer these results in record time. The formulation used in Vitaligenix T10 has a few key active ingredients that work to boost testosterone levels in as few as ten hours. Most other testosterone boosters take days to months to build up in the system and offer results. However, for those who don’t have time to wait around, Vitaligenix T10 will be able to offer better results in record time.
Ingredients in Vitaligenix T10
As mentioned above, Vitaligenix T10 is a liquid plasma capsule, meaning it contains a liquid center. By providing the complex formulation used for the supplement in liquid form, the ingredients can begin working faster than ever, offering better results quickly. However, it’s the ingredients of Vitaligenix T10 that truly deserve the praise. These ingredients work together to offer the best benefits possible to all users.
A list of the ingredients used in Vitaligenix T10, as well as a brief description of each ingredient, can be found below.
Tribulus Terrestris: Supports the vitality of users while also boosting testosterone levels.
Olea Europaea, Safed Musli Extract and Maca: Found in the Andes highlands, these ingredients are able to increase circulation and support the increase of testosterone levels
Zinc: Studies have found that zinc is able to maintain testosterone levels, keeping them steady as users take Vitaligenix T10.
Boron Citrate: Increases free testosterone in the body while decreasing estradiol.
Fenugreek Extract: Significantly increases bioavailable testosterone in users in record times, about ten hours.
Brassica Oleracea: Contains high levels of nitrogen to help the metabolizing of proteins.
While all these ingredients offer amazing benefits on their own, their true powers are seen when they’re combined. In the complex formulation of Vitaligenix T10, these ingredients are able to give users better results in about ten hours.
Purchasing Vitaligenix T10
Vitaligenix T10 is currently available for purchase on the GNC website (www.GNC.com), though more information on the supplement can be found on the supplement website (www.Vitaligenix.com). GNC is currently selling a bottle of Vitaligenix T10 (180 capsules) for $249.99, though members can get the same amount for $199.99, a 20% savings. For those who want Vitaligenix T10 auto delivered to them every 30-180 days, they can save 10% on the final price.
Click Here To See The #1 Rated Testosterone Boosting Supplement
Can 5 Cups of Coffee Boost Testosterone to Estrogen Ratio in Overweight Men Transiently by ~200%? Plus: SHBG Its Own Receptor and Its Role in Prostate & Breast Cancer
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| Testosterone booster in men and estrogen amplifier in women? As if there were not already enough good reasons to get your daily dose of the 'kingly' brew ;-) |
So what is it this time? What else can coffee do for you?
I guess something only few people others than SuppVersity readers will be aware of is the fact that caffeine and therefore coffee makes a nice testosterone booster (Beavon. 2008; study was discussed briefly as part of a longer post on June 20, 2012 an mentioned previous times in other posts) -- at least if you stick to moderate doses of ~300-400 mg before a workout. So, unless you are a newbie or missed the respective news, you should not be surprised that a recent study from the Harvard School of Public Health (Wedick. 2012), which had actually been designed mainly to investigate the effects of 5x 6-ounze cups caffeinated and decaffeinated coffee (both instant coffees; brand: NestlĂ©’s Taster’s Choice) on serum levels of sex hormone-binding globulin (SHBG), found that the consumption of both 'real' and 'fake' (=decaffeinated) instant coffee did lead to increases in total and free testosterone and profound decreases in estradiol (bound and free).
 |
| Figure 1: Levels of SHBG, testosterone, free testosterone, estradiol, free estrogen, the testosterone to estrogen ratio and DHEA in the male participants of the study expressed relative to a caffeine abstinent control group (Wedick. 2012) |
 |
| Figure 2: Levels of SHBG, testosterone, free testosterone, estradiol, free estrogen, the testosterone to estrogen ratio and DHEA in the female participants of the study expressed relative to a caffeine abstinent control group (based on Wedick. 2012) |
The relative data tells only part of the story
 |
| Figure 4: Absolute values of the testosterone to estrogen ratio after 4 and 8 weeks; baseline levels were 16.2, 15.8, 18.2 in the caffeinated coffee, decaffeinated coffee and control group respectively. The data clearly shows: Coffee needs a PCT ;-) |
Now this certainly reduces the effect size, but it does not totally negate the effect. After all the 'real' coffee drinkers (w/ caffeine) did still increase their T/E ratio from 16.2 to 24.2 -- a certainly likewise noteworthy increase of +29% that is however still far away from the exorbitant +189% increase compared to the poor guys who did not just lose their coffee, but also their virility.
So what does this tell use?
How cares about SHBG anyways? You should! After all there is relatively conclusive evidence that normal (not exorbitantly high!) SHGB levels have aprotective effect against breast cancer in women and mechanistic evidence that they increase the risk of prostate cancer in men. In both cases SHBG acts independently via the largely ignored SHBG receptor that modulates the action of estrogens. Co-activation of SHBG and estrogen receptor in the prostate induces similar effect on prostate specific antigen secretion as DHT (Nakhla. 1997). Since estrogen alone does not have this effect, it is no wonder that stinging nettle root (Urtica dioica), with its SHGB inhibiting effect is a viable tool in the treatment of benign prostatic hyperplasia (Hryb. 1995). In the female breast, on the other hand, SHBG seems to " trigger a 'biologic' anti-estrogenic pathway" (Fortunati. 1999) and does therefore exert anti-instead of pro-carcinogenic effects.
I guess there are more than just the following three lessons to learn from this study, but at the moment these appear to be the most important ones for me:- The beneficial effects habitual coffee intake has on type II diabetes risk are, contrary to the scientists hypothesis, not mediated by its effect on SHBG.
- In overweight men caffeine has a very shortlived beneficial effect on testosterone and the testosterone to estrogen ratio. After 4 weeks the levels do yet return to baseline, so this cannot explain the long-term benefits of habitual caffeine consumption either (maybe you should cycle caffeine instead of testosterone booster < I am just kidding ;-).
- In overweight women, there is a similar, yet negative effect on testosterone levels, which is likewise transient and lasts less than 8 weeks.
- The caffeine ads to the 'pro-testosterone' effects, but even decaffeinated coffee has some effects.
- Stopping "cold turkey" is not a good idea, when you are "on caffeine"
Regardless of whether you stop or start drinking coffeine, the endocrine "disturbances" are relatively short-lived and only further testimony to the fact that our bodies will always try to find a new "steady state" in what they consider normal.
Bottom line: There are a myriad of good reasons to drink coffee, getting more manly or more feminine is yet not one of them. Disappointed? Well, on the other hand this means coffee is no endocrine disruptor - and at least in this overweight population it seems to have a marginally beneficial baseline effects (thus the detrimental effects of abstinence).
Testosyn – XPI Supplements’ High Performance Testosterone?
http://supplementpolice.com/testosyn/
Contents of Six Star Testosterone Booster
Advantages of Six Star Testosterone Booster
In recent study in the International Journal of Sport Nutrition and Exercise Metabolism a group of researchers from theFaculty of Physical Education and Recreation at theUniversity of Alberta reports: "Supplementing a typical daily food intake consisting of 0.8 g of protein·kg-1·d-1 with a wheyprotein isolate (an additional 0.8 or 1.6 g·kg-1·d-1) [...] had no effect on glucose, insulin, testosterone, cortisol, or growth hormone following the final meal" (Forbes. 2013).
I know, anything else would have been a real shocker. What it wouldn't be, though, is a total surprise. If you dig through the available literature you can easily find data that would support the scientists' assumption that doing an experiment "to investigate the effects of a controlled typical one day diet supplemented with two different doses of whey protein isolate on blood amino acid profiles and hormonal concentrations following the final meal" (Forbes. 2013) would be a good idea.
True or false? Certainly TRUE!
No, I am not kidding you! We do have plenty of evidence of direct interactions between chronic high vs. low protein intake and the production and metabolism of hormones, like testosterone, cortisol, their corresponding binding proteins, SHGB and CBP, and a whole host of other molecules that act like hormones, although we often don't call them "hormones". Examples? Well, here you go:
Busted! D-Aspartic acid aka DAA is another "natural anabolic agent" that turns out to be more of a revenue- than a hormone-booster with muscle building prowess. And you know what? It took Darryn S. Willoughby and Brian Leutholtz from the Exercise and Biochemical Nutrition Lab, Human Performance, and Recreation at Baylor University exactly 28 days and 20 apparently healthy, recreationally active, resistance trained (3x per week or more in the past year) men with an average age of 22.8 ± 4.67 years (BMI 24.65 kg/m²) to prove that d-aspartic acid (DAA) supplements belong to this never-ending list of supplemental non-starters.
Things that work: 28 days, 4x per week heavy resistance training; things that don't work DAA capsules
Willoughby and Leutholtz assigned their participants in a random, double-blinded fashion to one of the two study arms. Subjects in both arms of the study followed a standardized periodized 28-day resistance training program split into 2 upper-extremity (A1, A2) and 2 lower-extremity (B1, B2) exercise sessions each week. With an overall training volume of 16 exercises sessions with 9x upper- and 8x lower-body exercises
That fact the whole hoopla was exactly that: All hype! is difficult to refute, if you take a look at the study outcomes in figure 1 or the researchers' conclusion:
Bottom line: Before we have counter-evidence (this is science guys, you can't say something definitive based on one study) there is no good reason for someone with normal testosterone levels to spend money on D-Aspartic acid supplements.
Whether the same would be true for guys on post-cycle therapy or those who want to combat diet- / overtraining induced reductions in testosterone would certainly be worth investigating. Other aspects that could make a difference are the form of delivery (although this did not seem to be a problem; after all the DAA levels rose) and the provision of adjuvants to block the negative feedback on the HPG (see explanation above).
References:
Most people know about the importance of testosterone. Even if it’s just the information gleaned from half-paying attention during a middle school Sex ED class, there’s a general amount of information out there about testosterone. Which is a good thing, since it’s such a vital part of how the male body works and operates.
While many associate testosterone with being the hormone that makes men virile, it actually plays two other big roles in the male body. The first is that testosterone helps keep the energy levels of men at a healthy level. This energy is vitally important for men to make it through their busy, stressful days. The second role that testosterone plays in the male body is it helps support and grow muscle mass. Between these two important factors, plus how it supports the libido, it’s no wonder that testosterone is so important to men.
Unfortunately, there’s a down side to testosterone. While men have high natural levels of testosterone in their bodies, as they get older, these levels begin to drop. As the body produces less and less testosterone, the important roles mentioned above begin to waver. Starting as early as 25, as these testosterone levels begin to dip, men start noticing their bodies acting differently.
Men with decreasing levels of testosterone are more tired than usual and can’t seem to focus on important tasks. They find it harder to gain muscle mass, having to fight to stop the fat that seems to be appearing on their bodies. And, their sexual libido seems to decrease significantly, causing them to become tenser and putting strains on their romantic relationships.
The problem is that many of the symptoms of low testosterone get shrugged off as being a natural part of aging. However, there are ways these symptoms can be reversed, giving back men the energetic, thriving lives they once had. And one of the most effective ways to increase testosterone in the body again is by taking Testosyn.
Testosyn is a testosterone booster that uses a variety of high quality ingredients to support the release of free testosterone in the body. By supporting this process, Testosyn is able give users back the lives they want, with better performance levels at work, in the gym, and in the bedroom.
What is Testosyn?
In order to help men regain their confidence and vigor for life, Testosyn was designed to help increase the production of free testosterone in the body. The supplement uses some of the best testosterone boosters available today, including several that have been scientifically found to aid in free testosterone production. By using the best ingredients and careful formulation, Testosyn has been able to change the lives of users, transforming them and their bodies.
The key to the power behind Testosyn is found in one of the most popular ingredients for testosterone enhancers today: Tribulus Terrestris. Research and clinical studies have found over and over again that this one ingredient is key to improving testosterone levels in men, naturally and safely. Due to the popularity of Tribulus Terrestris, it is found in dozens of products across the world. However, just because it’s listed on the ingredient label doesn’t mean it’s being used properly.
What sets Testosyn apart from so many other testosterone booster that use Tribulus Terrestris is the way the ingredient is used. The majority of supplement companies that claim to use the ingredient keep how much of the product they use to the minimum, instead packing the supplement full of fillers and other questionable ingredients. This is done in order to keep costs down. Testosyn, however, foregoes the fillers and instead packs the supplement full of saponins, which are the active compounds found in Tribulus Terrestris. In fact, Testosyn contains 140mg of a pure form of two different saponin extracts in order to give users better results in less time.
Benefits of Testosyn
All the benefits that come with Testosyn are due to the amazing ingredients, all of superior quality, found in the supplement. While a more detailed description of the ingredients found in Testosyn is below, the benefits of these ingredients are listed here.
The biggest benefit of Testosyn is that it is able to use the natural processes already at work within the male form to help it produce increased levels of free testosterone. The key to this benefit is found in the natural aspect of Testosyn. When the male body consumes ingredients that are at conflict with its natural processes, it can cause many horrible side effects. However, because Testosyn uses natural ingredients that fit flawlessly into an already moving system, the supplement is able to give better benefits in less time.
In addition to working with the body naturally, Testosyn is able to give men back all the amazing benefits that increased testosterone supports in men. A list of these benefits can be found below.
- Increases Lean Muscle Growth
- Burns Body Fat
- Decreases Recovery Time
- Increases Endurance
- Increases Sex Drive
- Supports Healthy Libido
- Increases Energy Levels
- Increases Focus
- Promotes Increased Drive
And all these amazing benefits come with taking Testosyn once a day. Better yet, all these benefits come by using a safe, natural, and effective supplement.
Ingredients in Testosyn
As mentioned above, the true power of Testosyn is found in its ingredients. Each of these ingredients was picked for a specific purpose and expertly measured and blended to offer users the best results. And, Testosyn also contains eight ingredients that have been clinically proven to support the production of free testosterone in the male form. Unlike so many other supplement manufacturers, Testosyn actually took the time to research and study these ingredients so that users would be able to get the best results each and every time they took the supplement.
A list of some of the active ingredients found in Testosyn can be found below, as well as brief description of each ingredient.
Fenusterols: An extract of fenugreek seed, this ingredient is able to increase free testosterone levels significantly, while supporting increased muscle mass, boosted energy levels, and an increased libido.
D-Aspartic Acid: An amino acid that is produced naturally by the body, this ingredient is also able to increase testosterone levels in the male body.
Boron: A powerful trace mineral that many people lack in their bodies, this nutrient is able to support bone health and strength, while also increasing testosterone levels in the body.
Tribulus Terrestris: The main ingredient in Testosyn, the herb increases sexual and athletic performances due to how itstimulates testosterone production. It also increases overall strength of users.
Horny Goat Weed: As its name suggests, this ancient herb has been known to increase the libido in users. An added benefit of the herb is that it can increase nitric oxide levels in the bloodstream, which aids in muscle growth.
For more ingredients used in Testosyn, as well as further details and scientific reports on the ingredients, customers should visit the Testosyn website (www.XPISupplements.com).
Purchasing Testosyn
There are currently three purchasing options available for those interested in getting started with Testosyn today. These options are listed below.
- 1 Bottle (60 Servings) – $59.95, Plus $5.95 Shipping and Handling
- 2 Bottles (120 Servings) – $109.95, Free Shipping
- 3 Bottles (180 Servings) – $169.95, Free Shipping
For a limited time, those who purchase two or more bottles of Testosyn will be given a free bottle of Xtreme ZMA, a supplement that aids in muscle growth, energy levels, and the libido.
Click Here To See The #1 Rated Testosterone Boosting Supplement
- Review of Six Star Testosterone Booster
Editor's Rating:
Six Star Testosterone Booster is a herbal pill usually available in stores. After a clear age, your body just plain doesn't give high testosterone as it used to. And it just keeps getting worse every year. While this is herbal and expected, it's not much adviced. Less testosterone means less gain muscle mass, smaller gains at the workout, low energy and power, lower sex drive, more belly fat... You get the thinking. So if you want to see vsible results at the gym or in the bedroom, you might see looking into testosterone supplementation of one kind or other.
There's hormone therapy which is clearly getting shots of actual synthetic testosterone. But that's reserved mainly for men with real and serious issues. For the male who just desires some of his mojo back, there are herbal testosterone increaser supplements, like Six Star Testosterone Booster. Due to the marketing materials, Six Star Testosterone Booster contains just what you need to like free testosterone, maintain the better cortisol to testosterone part, and increase your training performance.
Contents of Six Star Testosterone Booster
The Six Star website displays a bottle label that lays out all the contents that make up the formula: Boron,Ginkgo Biloba and Rhodiola Extract
Working Mechanism of Six Star Testosterone Booster
The thinking is that if Boron (and Six Star Testosterone Booster) can increase levels of free testosterone starting in 7 days, it can be a reason a significant increase over a longer period of usage.
The recommended amount is 2 capsules taken twice every day, once in the morning and once at night.
Advantages of Six Star Testosterone Booster
· It's very effective.
· The formula is based on laboratory tests.
· There are a lot of favorable Six Star Testosterone Booster overviews from customers who find it to be a good value for the money.
· It's available to buy in lots of local agents.
Where Can I Purchase?
You can see Six Star Testosterone Booster at local stores like Walmart and Walgreens for about $10 a bottle. You'll see similar prices online, but you may have to factor in sending if you go this way. A bottle contains 60 pills. At the adviced dose of 2 capsules two times everyday, the bottle will only finish 2 weeks, so the monthly price is more like $20, still low but not as low as $10.
Our Recommend
Six Star Testosterone Booster is one of those pills that gets increase in recommendation status because of its low cost. Everyone responds differently to different pills, so the only way to really know if something works for you is to use it. The low cost and wide availability of Six Star Testosterone Booster makes trying it useful.
How the best test boosters are helping men
A reduction in testosterone can sneak up on a man over time. Subtle symptoms like sluggishness, diminished sexual interest, and decreased muscle mass can often times seem like just a normal part of aging when it’s really an imbalance in a key hormone. Fortunately, the best test boosters are helping a growing number of men who want to increase their strength, endurance, stamina, vitality, and sexual function.
If you are experiencing an overall slowdown and wonder if low testosterone may be to blame, it’s a good idea to first consult with your physician. A simple blood test can determine your levels of testosterone which can help determine the best treatment options. These can include synthetic testosterone hormone replacement therapy, low testosterone supplements, or just making some changes to your lifestyle. Depending on your testosterone level, your doctor may recommend a combination of one or more treatments.
For most men who are simply suffering from testosterone loss due to age, natural treatments are typically the best choice because they do not have the side effects of hormone replacement therapy which can include breast enlargement, acne, heart problems, and even increased tumor production in men who have had prostate cancer.
Alternatively, the best test boosters on the market provide a revitalization of natural testosterone minus the side effects. One of the best low testosterone supplements is Ultra T Male Extended Release Bilayer Tablets.
These all natural low testosterone supplements help to promote healthy testosterone production to increase strength, endurance, vitality, brain function, mood, and sexual function. Because it is a bi-layered tablet, it begins to work immediately and deliver benefits throughout the day. It’s rapid-release layer delivers a variety of testosterone boosting nutrients including:
GlucodOX AMPX Booster: Helps to increase AMPK enzyme, a master regulator of hormone production.
Tongkat Ali: An aphrodisiac that has testosterone boosting properties.
Zinc Aspartate: Has been shown to increase free testosterone by increasing and regulating testosterone production.
Calcium: An important mineral used by the body’s hormone-producing enzymes to naturally create endogenous testosterone.
ViNitrox: A combination of grape and apple concentrates with high polyphenol content. This combination helps block peroxynitrite free radicals which have been shown to reduce testosterone levels.
Fenugreek: An herb that researchers are now finding to promote testosterone production and improve other indicators of male reproduction function.
Ultra T Male is an alternative to hormone replacement therapy that an increasing number of men are trying to avoid side effects and improve their natural testosterone production. Because these best of the best test boosters are not steroids or synthetic precursors, they are both safe and natural.
True or False - High or Low Protein Intakes Have Profound Influence on Testosterone, SHBG, Estrogen, Cortisol & Co?
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| We are what we eat! Acknowledged, but does this also go for your hormones and different in protein intakes? Let's have another look at the contemporarily available research to figure that out. |
I know, anything else would have been a real shocker. What it wouldn't be, though, is a total surprise. If you dig through the available literature you can easily find data that would support the scientists' assumption that doing an experiment "to investigate the effects of a controlled typical one day diet supplemented with two different doses of whey protein isolate on blood amino acid profiles and hormonal concentrations following the final meal" (Forbes. 2013) would be a good idea.
True or false? Certainly TRUE!
No, I am not kidding you! We do have plenty of evidence of direct interactions between chronic high vs. low protein intake and the production and metabolism of hormones, like testosterone, cortisol, their corresponding binding proteins, SHGB and CBP, and a whole host of other molecules that act like hormones, although we often don't call them "hormones". Examples? Well, here you go:
- Low protein = low SHBG (Longcope. 2000) - At least in the 1552 men in their "best age" (40-70 years) who participated in a study by scientsts from the University of Massachusetts Medical School the consumption of a diet that had less than the average 80g/day of protein in it lead to decreases in SHBG and corresponding increases in free (~bioavailable) testosterone. Age, dietary fiber, and smoking, on the other hand were positively correlated with SHBG.
- Chronically high protein intakes (40% of total energy) lower testosterone / cortisol ratio (Oi. 2001) - The highly significant increase in cortisol and corresponding decrease in the testosterone to cortisol ratio, Oi et al. report in a 2001 paper have luckily (a) been observed in rodents, only, and that's actually the main finding of the study (b) could be countered by the administration of garlic extract.
I can only speculate whether and to which degree the endocrine effects of high protein diets differ between rats and men (the Anderson study discussed below suggests they don't) - and you know I love facts and hate speculations and unsupported hypothesis. So I stick to an assumption I could support, i.e. the supposition that the improvements in testosterone, the researchers observed, when they fed their rodents garlic was mediated by its glutathione (GSH) boosting effects. These effects - and you as a regular SuppVersity reader know that are not "garlic exclusive". Whey protein, for example will also increase GSH (Bounous. 1989). Obviously whey doesn't increase your testosterone, but a "protein overload" from a glutathione boosting protein source may not have to be countered by GSH boosters in the first place.
Figure 1: In rodents, a high protein intake (40% of total energy from casein) will increase cortisol at stable T-levels and thus decrease the testosterone : cortisol ratio (Oi. 2001) - A high protein : carb ratio decreases total testosterone levels in man (Anderson. 1987) - Some people live by the principle that things that mustn't be. As a SuppVersityreader you obviously don't belong to this group of people and will thus be willing to accept that Anderson et al. were able to show that...
"[...] the testosterone concentrations in seven normal men were consistently higher after ten days on a high carbohydrate diet (468 ± 34 ng/dl, mean ± S.E.) than during a high protein diet (371 ± 23 ng/d1, p<0.05) and were accompanied by parallel changes in sex hormone binding globulin (32.5 ± 2.8 nmol/1 vs. 23.4 ± 1.6 nmol/1 respectively, p<0.01)." (Anderson. 1987)
As a SuppVersity reader you are yet also smart enough to know that this data is irrelevant, without adequately measured free testosterone levels: If we do the math and calculate the latter (obviously not 100% accurately), i.e. free testosterone on normal protein diet: 9.4 ng/dL = 2.01 % vs. free testosterone on high protein + low carb diet: 9.02 ng/dL = 2.43 %, the difference does no longer look so bad, anyway - does it?
This would not change the fact that you'd suffered a -42% decrease of the testosterone : cortisol ratio from 60.5 to 35 which occurred in the Anderson study, when the participants were put on a meat, fish, poultry, egg white, and protein supplement based 44% protein, 35% carbohydrates, 21% fat diet.
Figure 2: Total (TT in ng/dL) and free testosterone (FT in ng/dL), SHBG (µg/L) and testosterone : cotisol ratio after one months on high protein + low carb vs. control (Anderson. 1987) - A high protein very low calorie diet can increase testosterone levels, but it will do so only if it is used to produce significant weight loss in obese adolescents, whose abundant body fat stores are gnawing away their androgens. In a corresponding study by Brown et al., the eight 11-15-year-old boys and girls where put on liquid (starvation) diets with a protein / carb / fat ratio of 67% / 28% / 5% that containing a total of 492-709 kcal per day.
As you can see in Figure 3 the significant reduction in body weight (13.5 kg total, 70-75% fat) went hand in hand with improvements in insulin sensitivity and the previously mentioned increase in total testosterone levels in the 14 year-old subjects 3 & 7 and the 18 year-old male adolescents (subject 6) - the only subjects for whom a complete testosterone panel was available.
Figure 3: Total testosterone levels (ng/dl; left axis) and insulin levels (in µU/ml) in 14 (subj. 3 & 7) and 18 year-old male adolescents before and after 5 weeks on low calorie high protein liquid diets (Brown. 1983) - High protein diets are driving forces of GH induced skeletal muscle IGF-1 expression (Sanchez-Gomez. 1999) - With IGF-1 being equally important to men and women, it does not matter that the "subjects" in the study at hand were female growing rats that received either a high- or a low-protein diet with crude protein contents of 222 and 83 g/kg respectively.
After 14 days on which the rodents were concamittantly injected with saline control, or growth hormone (rhGH) or recombinant human IGF-I (rhIGF-I) at dosages of 350 and 500µg/day, respectively, Sanchez-Gomes et al. observed that
...the low-protein diet alone reduced IGF-I concentrations in serum and in tissue taken from the gastrocnemius muscle as well as IGF-I mRNA from the same muscle, significantly.Learn more about IGF-1. - ...the high protein diet amplified the retention of injected rhIGF-I in the muscle tissues and was associated with significant improvements of the nitrogen balance
- Increased f 2-hydroxylation of endogenous estrogen with high protein diets could have cancer protective effects (Anderson. 1984) - Certainly far fetched but not impossible is the connection between the increased 2-hydroxylation of endogenous estrogen in response to high protein diets Anderson et al. observed in a 1984 study in male study participants and the significant association between lower ratios an the risk of breast cancer (Liehr. 1996).
It goes without saying that this is nothing but a hypothesis - a hypothesis that would yet be supported by a 1999 paper on "dietary predictors of breast cancer recurrence and death" by Saxe et al. which is based on one of the few papers that did not control for "meat" intake (you know that Pizza Salami qualifies as "meat", right?) in which each 5% increase in protein intake was associated with risk reductions of 18% for breast cancer recurrence and 44% for death in premenopausal women (Saxe 1999).
Table 1: Cox regression of energy-adjusted dietary predictors of breast cancer recurrence and death (Saxe. 1999)
And what's more, the fact that the associations were less pronounced in the post-menopausal study participants (the "low estrogen counterpart", if you will; see Table 1) only support the notion that the protective effects of protein may (at least in part) be mediated by its effects on estrogen metabolism.
Vitamin D Supplementation(!) Increases Testosterone in Men
Thanks to Dashforce from the MindAndMuscle-Forum we finally have evidence for the direct effect ofvitamin D3 supplementation on testosterone in men. Dashforce reports on a study by scientists from Austria and Germany (Pilz. 2010) who provided 54 men, whose serum levels were previously at the lower range ~30ng/ml (the referential minimum varies depending on which source you cite from 30-50ng/ml),with either 83 μg (3 332 IU) vitamin D daily or placebo for 1 year.
As you can see in table 1,vitamin D supplementation lead to a significant increase in total testosterone from 10.7 nmol/l to 13.4 nmol/l. What's even more important, this increase (+25%) was not compensated by and an increase of SHGB, so that the amount of free testosterone rose from 0.222 n/mol to 0.267 nmol/l, i.e. by +20% (vs. +5% in the placebo group).
What is particularly interesting about this study is the fact that supplementation actually raised the level of testosterone. This is different from most previous studies, which observed a correlation between higher vitamin D levels and higher testosterone levels. If for example some probands would simply have been more healthy and thus exhibit higher levels of both, we would have had the same correlation. In the case of the Pilz study there is a clear causative effect between restauration of adequate vitamin D levels and increases in total and free testosterone.
I hope we see more trials with a similar design - also to investigate if there is a dose response relationship and whether even higher vitamin D levels would further increase testosterone. Until then, keep an eye on your vitamin D level and take a supplement to get to the upper ranges of the "normal" range ~80ng/ml.
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| Table 1: Characteristics of the study groups at baseline and at the end of the study |
What is particularly interesting about this study is the fact that supplementation actually raised the level of testosterone. This is different from most previous studies, which observed a correlation between higher vitamin D levels and higher testosterone levels. If for example some probands would simply have been more healthy and thus exhibit higher levels of both, we would have had the same correlation. In the case of the Pilz study there is a clear causative effect between restauration of adequate vitamin D levels and increases in total and free testosterone.
I hope we see more trials with a similar design - also to investigate if there is a dose response relationship and whether even higher vitamin D levels would further increase testosterone. Until then, keep an eye on your vitamin D level and take a supplement to get to the upper ranges of the "normal" range ~80ng/ml.
Testosterone Supplements and You
Often testosterone boosters are taken by body-builders for the sole purpose of gaining muscle. Athletes use testosterone to be able to work out longer and harder. Many of the testosterone supplements or boosters they use are artificial and boost testosterone levels way over the healthy limits. There are millions of these products floating about because marketers know that there is they can sell almost anything with a pretty label. Here we want to answer some basic questions like: What is testosterone? What is a natural testosterone supplement? Should the non-athlete think about testosterone supplements?
What is testosterone?
· Testosterone is a hormone. At puberty, testosterone plays a key role in giving teenage boys manly characteristics like facial hair and a deeper voice. Testosterone might be more noticeable at puberty but it is an essential part of every day for adult men as well. It allows the body to have enough energy, build more muscle and increase libido.
· While many take testosterone supplement what you may not know is the human body is able to produce its own testosterone. Usually cholesterol is converted into testosterone. That is why, diets that are rich in lean red meat and eggs (rich in cholesterol) are bad for heart disease, but are good for testosterone levels.
What is a natural testosterone supplement?
Supplements that are an amalgamation of different plant extracts alone are called natural testosterone supplements. There are a handful of plant extracts that have had significant success in boosting testosterone levels up to healthy limits. These extracts usually come alongside the body’s testosterone producing mechanism and lend a helping hand. They increase the free testosterone levels.
Should the non-athlete think about testosterone supplements?
If you’re not an athlete why would you need or want testosterone supplements? You might not know this but past the age of 30 testosterone levels in many men begin to decline. If you’re experiencing the following symptoms, it might be time to get a blood test done for testosterone levels.
· Constant fatigue
· Loss of muscle
· Lowered libido
· Depression
· Mood-swings
· Weight gain
Men who have low testosterone often chalk up these symptoms to mere old age. But that only worsens the condition. If left unattended, low testosterone levels can make bones porous, a condition called osteoporosis. Low testosterone also makes you more susceptible to being over-weight. Having low testosterone as you grow older just steals the joy of life away. That’s why it’s important to keep an eye on your testosterone levels and how natural supplements can help you.
One such natural supplement that has received very positive reviews of Ageless Male. Ageless Male supplement contains an extract from ripe fenugreek seeds called Testofen and has been clinically shown to increase levels of free testosterone in healthy men.
You might not need testosterone supplements yet but it’s good to know what the best products are and why. It’s also good to be prepared to tell others to check their testosterone levels so that everyone can live a normal healthy life for years to come.
What is testosterone?
· Testosterone is a hormone. At puberty, testosterone plays a key role in giving teenage boys manly characteristics like facial hair and a deeper voice. Testosterone might be more noticeable at puberty but it is an essential part of every day for adult men as well. It allows the body to have enough energy, build more muscle and increase libido.
· While many take testosterone supplement what you may not know is the human body is able to produce its own testosterone. Usually cholesterol is converted into testosterone. That is why, diets that are rich in lean red meat and eggs (rich in cholesterol) are bad for heart disease, but are good for testosterone levels.
What is a natural testosterone supplement?
Supplements that are an amalgamation of different plant extracts alone are called natural testosterone supplements. There are a handful of plant extracts that have had significant success in boosting testosterone levels up to healthy limits. These extracts usually come alongside the body’s testosterone producing mechanism and lend a helping hand. They increase the free testosterone levels.
Should the non-athlete think about testosterone supplements?
If you’re not an athlete why would you need or want testosterone supplements? You might not know this but past the age of 30 testosterone levels in many men begin to decline. If you’re experiencing the following symptoms, it might be time to get a blood test done for testosterone levels.
· Constant fatigue
· Loss of muscle
· Lowered libido
· Depression
· Mood-swings
· Weight gain
Men who have low testosterone often chalk up these symptoms to mere old age. But that only worsens the condition. If left unattended, low testosterone levels can make bones porous, a condition called osteoporosis. Low testosterone also makes you more susceptible to being over-weight. Having low testosterone as you grow older just steals the joy of life away. That’s why it’s important to keep an eye on your testosterone levels and how natural supplements can help you.
One such natural supplement that has received very positive reviews of Ageless Male. Ageless Male supplement contains an extract from ripe fenugreek seeds called Testofen and has been clinically shown to increase levels of free testosterone in healthy men.
You might not need testosterone supplements yet but it’s good to know what the best products are and why. It’s also good to be prepared to tell others to check their testosterone levels so that everyone can live a normal healthy life for years to come.
When Hype Meets Reality: D-Aspartic Acid Turns Out to Be Another Supplemental Nonstarter in First Human Trial With Any Relevance for Healthy Young Men
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| Training "on" D-Aspartic Acid is like training on guar gum. |
Things that work: 28 days, 4x per week heavy resistance training; things that don't work DAA capsules
Willoughby and Leutholtz assigned their participants in a random, double-blinded fashion to one of the two study arms. Subjects in both arms of the study followed a standardized periodized 28-day resistance training program split into 2 upper-extremity (A1, A2) and 2 lower-extremity (B1, B2) exercise sessions each week. With an overall training volume of 16 exercises sessions with 9x upper- and 8x lower-body exercises
- A1, A2 - upper body: bench press, lat pull, shoulder press, seated rows, shoulder shrugs, chest flies, biceps curl, triceps press down, and abdominal curls
- B1, B2 - lower body: leg press, or squat, back extension, step ups, leg curls, leg extension,heel raises, and abdominal crunches
- 4 capsules containing 3 g of guar gum (PLA), or
- 4 capsules containing 3 g of D-ASP (Better Body Sports, Ventura, CA, USA)
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| Figure 1: Endocrine and body composition changes with placebo or DAA supplementation (Willoughby. 2013) |
"[...] 28 days of D-ASP of supplementation at a daily dose of 3 g is ineffective in upregulating the activity of the HPG axis and has no preferential effects in which to increase skeletal muscle mass and strength in resistance-trained men." (Willoughby. 2013)In their discussion of what might be the physiological reasons for the non-existent effects on the gonadal production of testosterone the researchers state:
Or to put is simply: If DAA works at all, it works only in guys like the participants of the 2009 study by Topo et al. who had baseline testosterone levels at the lower end of the normal range (4.5ng/ml) at the beginning of the study and average levels (6.4ng/ml) at the end of the study period. In trained athletes with testosterone levels in the range of 8ng/ml such as the guys in the Willoughby study the negative feedback will prevent any further increase in testosterone."Based on our data presented herein, this [=the fact that the serum levels of DAA were higher than normal, but nothing happened] may indicate another potential mechanistic reason why the HPG [hypothalamus > pituitary > gonads] axis was not affected by D-ASP supplementation. Although we observed nonsignificant increases in serum D-ASP in the DAA group, we showed significant increases in DDO levels in response to D-ASP supplementation. The degradative role of DDO is to catalyze the oxidative deamination of D-amino acids to generate the corresponding 2-oxo acids, along with hydrogen peroxide and ammonia (or methylamine).
Figure 2: Comparison of the hormonal effect of DAA in sedentary men with low testosterone levels (Topo. 2009) vs. trainees with normal to high levels of testosterone (Willoughby. 2013)
In rodents, the administration of D-ASP was shown to increase DDO activity (Nagasaki. 1994; Yamada.1989), suggesting that DDO activity is induced by increased levels of D-ASP. Based on this information, in the present study, it is possible that because of the higher baseline levels of testosterone, as a means of androgen-regulated feedback of the HPG axis, the level of serum D-ASP induced by supplementation was conceivably being degraded by DDO at a rate that rendered it unable to effectively activate the HPG axis." (Willoughy. 2013)
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| Does testosterone actually build muscle and are natty test boosters worth your money? (learn more) |
Whether the same would be true for guys on post-cycle therapy or those who want to combat diet- / overtraining induced reductions in testosterone would certainly be worth investigating. Other aspects that could make a difference are the form of delivery (although this did not seem to be a problem; after all the DAA levels rose) and the provision of adjuvants to block the negative feedback on the HPG (see explanation above).
References:
- Nagasaki H. Gender-related differences of mouse liver-D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators. Int J Biochem 1994;26:415–23.
- Shelmadine B, Cooke M, Buford T, Hudson G, Redd L, Leutholtz B, et al. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-shotgun, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males. J Int Soc Sports Nutr
2009;6:16. - Spillane M, Schwarz N, Leddy S, Correa T, Minter M, Longoria V, et al. Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-shotgun and NO-synthesize on body com position, muscle strength and mass, markers of protein synthesis, and clinical safety markers in males. Nutr Metab (Lond) 2011;8:78
- Topo E, Soricelli A, D'Aniello A, Ronsini S, D'Aniello G. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol 2009;7:120
- Willoughby DS, Leutholtz B. d-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutrition Research, Available online 15 August 2013.
- Yamada R, Nagasaki H, Nagata Y, Wakabayashi Y, Iwashima A. Administration ofD-aspartate increasesD-aspartate oxidase activity in mouse liver. Biochim Biophys Acta 1989;990:325–8.
Increase Natural Testosterone for a Ripped Physique?
Pushing yourself at the gym is an exhilarating and energizing experience. But even the best efforts can still have a shortfall in results. If you are like the many men who spend hours at the gym and who work to cultivate a healthy diet, but are still frustrated with the lack of a ripped physique, then you may have low testosterone levels. Male testosterone is an essential component for muscle growth and without this vital compound, you’ll still retain your boyish body.
To remedy the low testosterone, you need a testosterone booster such as Musculus X. This supplement is known to stack up well against other testosterone supplements on the market and better yet, it leads to results. Here is everything you need to know about Musculus X before you add it to your workout routine.
For those of you who are ready to take your workout routine to the next level and to experience the larger, more powerful, and ripped muscles that you’re working so hard for, then it is time to realize the power of Musculus X and what it can do for you.
Luckily, Musculus X does not contain any fillers, additives, synthetic ingredients, or low-quality substances. The product’s premium formula is made with high-grade ingredients that work to improve you with the expected results. All of the ingredients are also completely natural so that you can achieve muscle growth in the safest manner possible.
After all, you do need to give the supplement time to work.
When taking this supplement, it is imperative that you follow your regular fitness regimen and maintain a healthy diet. In doing so, you can ensure that the supplement is working at its optimal level to provide you with excellent results so that you can meet your weight loss goals. This does not mean that you cannot enjoy a beer or a hearty burger ones in a while, but it is best to limit your high-calorie, sugar, and fat intake to a minimum.
Half of the men received Musculus X, while the other half were given a placebo. The men maintained the same moderate workout routine and were asked to increase their routine every week. At the end of the 8 week clinical trial, the researchers analyzed the men’s testosterone levels, muscle growth, and recorded testimonials. The researchers concluded that Musculus X leads to the following results, on average:
As you can tell, the ingredients in Musculus X promote the bodily functions for muscle growth. The ingredients in the product are completely safe and are not meant to cause you any adverse side effects.
Testosterone is the hormone that grows boys into guys. It is difficult to picture adult males without having this hormone. It not only controls your sexual and erectile operate but is also the hormone behind your aggressive conduct. It is the hormone that is accountable for offering your individuals challenging muscle tissues.
Nonetheless, the creation of this hormone starts plummeting following thirty at about one% a yr. What it indicates is that by the time you attain forty, you are currently ten% brief of your regular testosterone ranges. Some males shed testosterone at a greater rate and really feel the results sharply.
Some of the most typical results of low testosterone in your physique consist of low libido, erectile dysfunction, low power ranges, rest apnea, mood swings and irritable conduct and so on., A lose in testosterone triggers a great deal of physique and behavioral modifications.
Although particular way of life modifications can assist increase testosterone amounts in your entire body, testosterone dietary supplements are a great assist.
Testosterone dietary supplements, can aid increase your entire body increase i ts very own testosterone creation. These kinds of health supplements are created with very best herbal extracts and other all-natural substances that are totally protected and normal and not only increase your sexual potency and virility but also aid supply a full physique makeover.
Some of the normal components employed in These dietary supplements consist of ginkgo biloba, tribulus terrestris, extended jack, l-arginine, panax ginseng, muira pauma and so on.,
Individuals herbs have been utilised given that historical occasions to heal a variety of kind of male wellbeing troubles and ailments. People dietary supplements not only increase testosterone manufacturing but also assist boost blood movement to the penis. This is critical in escalating male libido and guaranteeing rock reliable erections.
Apart from this, top rated good quality testosterone dietary supplements also aid promote progress hormone manufacturing. Progress hormone or HGH is the grasp hormone in your entire body and escalating HGH ranges effortlessly aids slow down and even reverse age results to a great extent. In fact, HGH enhancers, are intended to be the greatest anti aging resolution till date.
Some of the positive aspects of These testosterone boosting health supplements contain:
As These kinds of, there is hardly something in your entire body that stays untouched. What has manufactured This kind of health supplements more and more common is that they are risk-free and totally free of aspect results. Excellent high quality dietary supplements are clinically authorized and endorsed by well reputed medical doctors as well.
So, if You Want to Increase Testosterone in your Physique, Check out out the Most Powerful and all All-natural Testosterone Supplement for Males.
To remedy the low testosterone, you need a testosterone booster such as Musculus X. This supplement is known to stack up well against other testosterone supplements on the market and better yet, it leads to results. Here is everything you need to know about Musculus X before you add it to your workout routine.
About Musculus X
Musculus X is a popular muscle enhancer throughout Europe, particularly in Germany and now, it is starting to break through in the US market. The supplement is designed to provide you with a muscular and ripped body by boosting your testosterone levels. While there are many benefits to using this supplement in terms of muscles and growth, many men also tend to experience another side advantage, which is greater libido and sexual prowess.For those of you who are ready to take your workout routine to the next level and to experience the larger, more powerful, and ripped muscles that you’re working so hard for, then it is time to realize the power of Musculus X and what it can do for you.
No Fillers or Additives
Before adding any muscle building supplement to your diet, it is vital that you are mindful of the ingredients. After all, all too often you hear about supplements that have adverse side effects that have led some unfortunate guy to suffer.Luckily, Musculus X does not contain any fillers, additives, synthetic ingredients, or low-quality substances. The product’s premium formula is made with high-grade ingredients that work to improve you with the expected results. All of the ingredients are also completely natural so that you can achieve muscle growth in the safest manner possible.
Fast Results
Dissimilar to other supplements on the market, Musculus X also provides you with quick results. Those who use the supplement on a regular basis and as directed will notice the supplement working instantly to improve energy levels, muscle recovery time, performance at the gym, and strength. Other results, such as noticeable muscle growth, a toned body, and a ripped physique start to appear within a few weeks of use.After all, you do need to give the supplement time to work.
When taking this supplement, it is imperative that you follow your regular fitness regimen and maintain a healthy diet. In doing so, you can ensure that the supplement is working at its optimal level to provide you with excellent results so that you can meet your weight loss goals. This does not mean that you cannot enjoy a beer or a hearty burger ones in a while, but it is best to limit your high-calorie, sugar, and fat intake to a minimum.
Proven to Work
In choosing a supplement, another quality that you should be aware of is the product’s ability to provide you with significant results. The good news is that when it comes to Musculus X, this supplement has been constantly tested in clinical trials. The latest clinical trial gathered a group of 100 men.Half of the men received Musculus X, while the other half were given a placebo. The men maintained the same moderate workout routine and were asked to increase their routine every week. At the end of the 8 week clinical trial, the researchers analyzed the men’s testosterone levels, muscle growth, and recorded testimonials. The researchers concluded that Musculus X leads to the following results, on average:
- 47% increase in testosterone levels
- 65% enhancement in muscle growth
- 54% increase in energy levels
- 30% increase in performance and ability to lift heavier weights
The Key Ingredients
The best supplements on the market have excellent and reliable ingredients. Musculus X is a supplement that you can count on to provide you with ingredients that are powerful and that are known to work. The supplement contains the following substances:L-Arginine Alpha Ketoglutarate
Known as AAKG, for short, this supplement is an important amino-acid that enhances your body’s nitric oxide levels. Nitric Oxide promotes larger veins in your body so that the blood can circulate better to your muscles. With improved circulation, your muscles receive nutrients, minerals, and amino acids necessary for substantial growth. The nitric oxide is also known to increase your metabolism and to burn fat so that you achieve lean muscle growth.Testosterone Boosters
The second ingredient is a proprietary blend of ingredients that work to enhance your testosterone levels. With higher testosterone levels, you’ll have more energy throughout the day, you will be able to lift more at the gym, and you will experience substantial performance no matter what task you undertake. The higher testosterone also aids in sexual libido so that you can impress your partner in the bedroom again.As you can tell, the ingredients in Musculus X promote the bodily functions for muscle growth. The ingredients in the product are completely safe and are not meant to cause you any adverse side effects.
Summary
Musculus X is a highly recommended muscle enhancer. The supplement focuses on increasing your free testosterone and nitric oxide levels. With these types of compounds flourishing in your body, you will be able to finally achieve the ripped, powerful, toned, and lean physique that you have been working so hard for. Moreover, the natural formula improves your energy levels so that you are always motivated to hit the gym, and hard.
Click Here To See The #1 Rated Testosterone Boosting Supplement
Testosterone Supplements For Men - Powerful Erections, Robust Sex Drive and Increased Stamina
Testosterone is the hormone that grows boys into guys. It is difficult to picture adult males without having this hormone. It not only controls your sexual and erectile operate but is also the hormone behind your aggressive conduct. It is the hormone that is accountable for offering your individuals challenging muscle tissues.
Nonetheless, the creation of this hormone starts plummeting following thirty at about one% a yr. What it indicates is that by the time you attain forty, you are currently ten% brief of your regular testosterone ranges. Some males shed testosterone at a greater rate and really feel the results sharply.
Some of the most typical results of low testosterone in your physique consist of low libido, erectile dysfunction, low power ranges, rest apnea, mood swings and irritable conduct and so on., A lose in testosterone triggers a great deal of physique and behavioral modifications.
Although particular way of life modifications can assist increase testosterone amounts in your entire body, testosterone dietary supplements are a great assist.
Testosterone dietary supplements, can aid increase your entire body increase i ts very own testosterone creation. These kinds of health supplements are created with very best herbal extracts and other all-natural substances that are totally protected and normal and not only increase your sexual potency and virility but also aid supply a full physique makeover.
Some of the normal components employed in These dietary supplements consist of ginkgo biloba, tribulus terrestris, extended jack, l-arginine, panax ginseng, muira pauma and so on.,
Individuals herbs have been utilised given that historical occasions to heal a variety of kind of male wellbeing troubles and ailments. People dietary supplements not only increase testosterone manufacturing but also assist boost blood movement to the penis. This is critical in escalating male libido and guaranteeing rock reliable erections.
Apart from this, top rated good quality testosterone dietary supplements also aid promote progress hormone manufacturing. Progress hormone or HGH is the grasp hormone in your entire body and escalating HGH ranges effortlessly aids slow down and even reverse age results to a great extent. In fact, HGH enhancers, are intended to be the greatest anti aging resolution till date.
Some of the positive aspects of These testosterone boosting health supplements contain:
- higher power ranges
- elevated heart and prolonged purpose
- increased cholesterol profile
- higher muscle mass and low human body excess fat
- elevated libido and rock reliable erections
- far better mood and rest good quality
- denser and more powerful bones
- greater psychological alertness and so forth.,
As These kinds of, there is hardly something in your entire body that stays untouched. What has manufactured This kind of health supplements more and more common is that they are risk-free and totally free of aspect results. Excellent high quality dietary supplements are clinically authorized and endorsed by well reputed medical doctors as well.
So, if You Want to Increase Testosterone in your Physique, Check out out the Most Powerful and all All-natural Testosterone Supplement for Males.
Natural Testosterone Boosters By Jerry Brainum
Are They for Real?
In 1984 I was asked to write an article about ergogenic aids for a national sports magazine. It was to be included in a special issue covering the Summer Olympic Games that year. I interviewed a number ofexperts. One, a medical doctor, told me off the record that he had about 20 Olympic athletes on a regimen that included anabolic steroids and growth hormone. Significantly, none of the athletes got busted during the Olympics. While the guy was forthcoming—although he refused to identify the athletes using the drugs—other experts proved far more secretive.
I called a man in Boston who was described to me as a “well-known physician.” He had extensive experience with a little-known substance calledSmilax officinalis, which I understood was some kind of herbal concoction, but when I called “Dr. X”—he refused to divulge his real name—he told me that he wasn’t at liberty to provide any details about Smilax. It wasn’t until later that I found out that Smilax officinaliswas actually sarsaparilla, a common flavoring in root beer. A search for the anabolic effects of the plant turned up one obscure connection related to natural compounds called plant sterols.
Flashback to 1942. A renegade chemist from the University of Pennsylvania named Russell Marker was acting like Indiana Jones, searching for plants with special properties in the wilds of Mexico. At the time, steroid hormones, including testosterone, were being produced in a very expensive process. Working in his lab in 1936, Marker successfully developed a method of producing chemical steroids from plant sterols. All steroids are made from the parent compound, cholesterol. When Marker noticed that plant sterols, which are the plant versions of cholesterol, have a close structural similarity to cholesterol, he was able to produce a human steroid from sarsaparilla. It was too expensive, though, to be used in mass quantities; hence Marker’s Mexican trek.
Marker found his ideal substitute in the Mexican yam. Diosgenin, a plant sterol in the yam, proved to be an effective substrate for steroid production. Through a five-step process involving the use of various enzymes, Marker successfully produced the steroid progesterone. The first major steroid produced from cholesterol, progesterone is the precursor of other steroid hormones, including estrogen and testosterone.
Marker offered his discovery to drug companies, but they all turned him down except for a small, little-known company called Syntex. Syntex eventually became a major producer of hormone drugs, including a number of anabolic steroids. Meanwhile, the Mexican yam and diosgenin became the major raw materials for steroid hormones, particularly birth control pills, until they were supplanted by a synthetic process in 1970.
Mexican yams were also sold as a food supplement because of their plant sterol content. In fact, early forms of supplemental DHEA primarily contained Mexican yam extract. That proved problematic, since the yam itself doesn’t contain any active steroid hormones, including DHEA. The poor quality and ineffectiveness of the supplements led to their removal from the market in 1987 by the Food and Drug Administration. Real DHEA turned up a few years later, thanks to the Dietary Supplement Health and Education Act of 1994.
It’s no secret that anabolic steroids help build muscle size and strength. The problem with steroids is twofold. First, they’re prescription drugs and have potentially serious side effects. Second, most doctors are loath to prescribe them, knowing how easily they can be abused by those seeking to build muscle. That led to the pro-hormone industry, which began with legitimate DHEA supplements and ended with the advent of the Anabolic Steroid Drug Amendment in 2005.
Not much better than DHEA, the initial pro-hormones were far worse from a health perspective. They offered little in the way of true anabolic activity but plenty in the way of anabolic-steroid-related side effects, including rapid conversion into estrogen. The last generation of pro-hormones was far improved, since many were actual anabolic steroids that were never released by the companies that researched them—and for good reason. Most of them had too many side effects, such as being hard on the liver. Even worse, evidence for significant anabolic effect in humans was lacking.
After the FDA banned pro-hormone supplements, supplement companies catering to bodybuilders and athletes were temporarily at a loss. What could they do to maintain their lucrative sales? A few threw all caution to the wind by attempting to sell a few more rejected steroid compounds, while others began to surreptitiously include a new category of steroids, called “designer steroids,” since they were supposedly not detectable by the usual drug screens. That proved short-lived, for the FDA was on the lookout for any substance that could directly convert into testosterone, which put it in direct violation of the 2005 steroid amendment.
Now, how to explain the current plethora of supplements advertised as boosting testosterone? What the supplement companies did amounted to going back in time. Most of the products are based on plant compounds, which makes them completely legal in the eyes of the FDA. The more important question is, Are they effective?
Some of the more unscrupulous companies resorted to highly questionable tactics. For example, many current pro-hormone supplements are based on DHEA, but it’s usually called something else. That’s a common tactic today—listing complex chemical names to make consumers believe that a supplement contains a new and revolutionary compound. Another likely motive is that the chemical nomenclature imparts a druglike aura to the product. DHEA is not junk; it benefits those whose bodies produce low amounts of it. As a testosterone-booster, though, it’s effective only for women.
Plants don’t actually contain real testosterone but rather plant sterols. The human body lacks the enzymes required to convert plant sterols into true steroids, although it can be done in a lab. That explains why plant sterols were—and in some cases still are—used to produce steroid drugs. One plant known to contain an actual androgen—the truffle—is a type of mushroom. Truffles naturally contain a very weak androgen called androst-16-en-3-ol. It isn’t very anabolic, which explains why you don’t see any mushrooms competing for the Mr. Olympia title.
Perhaps the foremost herbal testosterone booster is Tribulus terrestris, which grows wild in Bulgaria and elsewhere. Tribulus contains various plant sterols, including diosgenin. Most of the sterols are categorized as saponins, since they produce a soaplike effect when metabolized. The active anabolic ingredient in tribulus is a saponin called protodioscin.
Purveyors of tribulus often note that if it doesn’t contain enough protodioscin, it’s useless for building muscle, although it does have other properties, including diuretic effects and coronary artery dilation. Normally tribulus contains about 5 percent protodioscin. One study analyzed commercial tribulus supplements for their protodioscin content. It varied, with samples from Bulgarian sources having more and those from China and India the least. Quality control is a real problem with tribulus, as it is with many other herbal supplements.
Tribulus came to the attention of Western athletes after poorly controlled Russian research revealed that it increased testosterone. The initial studies involved animals, such as rams. In the human studies that followed, tribulus was given to men with clinically low testosterone levels. One study found that men receiving 750 milligrams of tribulus daily for five days showed a 72 percent increase in luteinizing hormone, along with a 40 percent rise in testosterone. Less publicized was the accompanying 81 percent rise in estrogen.
Luteinizing hormone is produced in the pituitary gland and governs the production of testosterone in the testes. It’s suggested that tribulus contains a substance called harmine that blunts the breakdown of an enzyme in the brain that degrades dopamine. Elevated dopamine encourages the production of not only luteinizing hormone and subsequent testosterone but also growth hormone. The much touted “active” tribulus ingredient, protodioscin, aids DHEA synthesis and release.
Based on these mechanisms, tribulus should indeed be an efficient testosterone booster, although increasing DHEA wouldn’t have much of an anabolic effect in young men. Animal studies seem to confirm the hormone-boosting effect of tribulus. One recent study, in which primates, rats and rabbits were given a tribulus extract intravenously, resulted in a 52 percent increase in testosterone, a 31 percent rise in the testosterone metabolite DHT and a 29 percent rise in DHEA-S in the primates. The rats in the study were castrated but still experienced a 51 percent rise in testosterone. Rabbits didn’t fare as well, showing mainly a 32 percent increase in undesirable DHT.1 Another study showed that giving rats tribulus protected against diabetes through antioxidant activity.2
Animal studies can’t always be extrapolated to humans. While the research on tribulus emanating from Russia is nothing short of glowing, the herb hasn’t fared as well under Western scientific scrutiny. One study involved 15 men who got either a placebo or tribulus at a dose of 3.21 milligrams per kilogram of bodyweight daily. The subjects followed an eight-week weight-training routine. Muscle endurance increased on the bench press and leg press in the placebo group, while those in the tribulus group showed an increase only in leg press strength. No changes in body composition occurred in either group.3
Another study examined the effects of either a placebo or 450 milligrams a day of tribulus in 22 rugby players who were engaged in weight training for five weeks. Both groups produced similar gains, along with no rise in testosterone in the tribulus group.4Still another study looked at whether tribulus raises testosterone in young men. The 21 subjects took either tribulus or a placebo for four weeks. Tribulus had no effect.5
Given that tribulus can raise estrogen, it’s not surprising that there’s at least one case study on record of a young bodybuilder who acquired gynecomastia, or male breast formation, after using a tribulus supplement.6 DHEA can easily convert into estrogen, particularly in younger men, although it more often converts into a metabolite of DHT.
One company is selling what it calls a “potent testosterone booster” based on the herb fenugreek. According to the company’s claims, substances in fenugreek called fenusides promote a significant rise in free, or active, testosterone. The company mentions a study in which 55 men, aged 18 to 35, all actively involved in weight training, were divided into two groups, with 29 receiving the fenugreek product and 26 getting a placebo. The subjects were evaluated three times over the eight-week course of the study. Those in the fenugreek group showed a 100 percent rise in free testosterone compared to the placebo group, along with a reduction in skin folds, pointing to lowered bodyfat.
Sounds impressive, until you realize that this was an unpublished study done by the company making the product. No other details of the experiment were mentioned. Interestingly, fenugreek contains some of the same plant sterols found in tribulus, including protodioscin, as well as diosgenin, which was as found in Mexican yams. It contains a unique amino acid called 4-hydroxyisoleucine that has an effect similar to insulin in aiding glucose uptake. One study of cyclists showed that fenugreek seemed to increase the efficiency of muscle glycogen repletion when taken with glucose, which is precisely what insulin does.
I’ll have more on testosterone boosters next month.
1 Gauthaman, K., et al. (2008). The hormonal effects of tribulus terrestris and its role in the management of male erectile dysfunction—an evaluation using primates, rabbit, and rat. Phytomed. 15:44-54.
2 Lotfy, A.A., et al. (2006). The protective effect of tribulus terrestris in diabetes. Ann NY Acad Sci. 1084:391-401.
3 Antonio, J., et al. (2000). The effects of tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab. 10:208-15.
4 Rogerson, S., et al. (2007). The effect of five weeks of tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Str Cond Res. 21:348-53.
5 Neychev, V.K., et al. (2005). The aphrodisiac herb tribulus does not influence the androgen production in young men. J Ethnopharmacol. 101:319-23.
6 Jameel, J.K., et al. (2004). Gynecomastia and the plant product “tribulus terrestris.”Breast. 13:428-30.
In 1984 I was asked to write an article about ergogenic aids for a national sports magazine. It was to be included in a special issue covering the Summer Olympic Games that year. I interviewed a number ofexperts. One, a medical doctor, told me off the record that he had about 20 Olympic athletes on a regimen that included anabolic steroids and growth hormone. Significantly, none of the athletes got busted during the Olympics. While the guy was forthcoming—although he refused to identify the athletes using the drugs—other experts proved far more secretive.I called a man in Boston who was described to me as a “well-known physician.” He had extensive experience with a little-known substance calledSmilax officinalis, which I understood was some kind of herbal concoction, but when I called “Dr. X”—he refused to divulge his real name—he told me that he wasn’t at liberty to provide any details about Smilax. It wasn’t until later that I found out that Smilax officinaliswas actually sarsaparilla, a common flavoring in root beer. A search for the anabolic effects of the plant turned up one obscure connection related to natural compounds called plant sterols.
Flashback to 1942. A renegade chemist from the University of Pennsylvania named Russell Marker was acting like Indiana Jones, searching for plants with special properties in the wilds of Mexico. At the time, steroid hormones, including testosterone, were being produced in a very expensive process. Working in his lab in 1936, Marker successfully developed a method of producing chemical steroids from plant sterols. All steroids are made from the parent compound, cholesterol. When Marker noticed that plant sterols, which are the plant versions of cholesterol, have a close structural similarity to cholesterol, he was able to produce a human steroid from sarsaparilla. It was too expensive, though, to be used in mass quantities; hence Marker’s Mexican trek.
Marker found his ideal substitute in the Mexican yam. Diosgenin, a plant sterol in the yam, proved to be an effective substrate for steroid production. Through a five-step process involving the use of various enzymes, Marker successfully produced the steroid progesterone. The first major steroid produced from cholesterol, progesterone is the precursor of other steroid hormones, including estrogen and testosterone.
Marker offered his discovery to drug companies, but they all turned him down except for a small, little-known company called Syntex. Syntex eventually became a major producer of hormone drugs, including a number of anabolic steroids. Meanwhile, the Mexican yam and diosgenin became the major raw materials for steroid hormones, particularly birth control pills, until they were supplanted by a synthetic process in 1970.
Mexican yams were also sold as a food supplement because of their plant sterol content. In fact, early forms of supplemental DHEA primarily contained Mexican yam extract. That proved problematic, since the yam itself doesn’t contain any active steroid hormones, including DHEA. The poor quality and ineffectiveness of the supplements led to their removal from the market in 1987 by the Food and Drug Administration. Real DHEA turned up a few years later, thanks to the Dietary Supplement Health and Education Act of 1994.
It’s no secret that anabolic steroids help build muscle size and strength. The problem with steroids is twofold. First, they’re prescription drugs and have potentially serious side effects. Second, most doctors are loath to prescribe them, knowing how easily they can be abused by those seeking to build muscle. That led to the pro-hormone industry, which began with legitimate DHEA supplements and ended with the advent of the Anabolic Steroid Drug Amendment in 2005.
Not much better than DHEA, the initial pro-hormones were far worse from a health perspective. They offered little in the way of true anabolic activity but plenty in the way of anabolic-steroid-related side effects, including rapid conversion into estrogen. The last generation of pro-hormones was far improved, since many were actual anabolic steroids that were never released by the companies that researched them—and for good reason. Most of them had too many side effects, such as being hard on the liver. Even worse, evidence for significant anabolic effect in humans was lacking.
After the FDA banned pro-hormone supplements, supplement companies catering to bodybuilders and athletes were temporarily at a loss. What could they do to maintain their lucrative sales? A few threw all caution to the wind by attempting to sell a few more rejected steroid compounds, while others began to surreptitiously include a new category of steroids, called “designer steroids,” since they were supposedly not detectable by the usual drug screens. That proved short-lived, for the FDA was on the lookout for any substance that could directly convert into testosterone, which put it in direct violation of the 2005 steroid amendment.
Now, how to explain the current plethora of supplements advertised as boosting testosterone? What the supplement companies did amounted to going back in time. Most of the products are based on plant compounds, which makes them completely legal in the eyes of the FDA. The more important question is, Are they effective?
Some of the more unscrupulous companies resorted to highly questionable tactics. For example, many current pro-hormone supplements are based on DHEA, but it’s usually called something else. That’s a common tactic today—listing complex chemical names to make consumers believe that a supplement contains a new and revolutionary compound. Another likely motive is that the chemical nomenclature imparts a druglike aura to the product. DHEA is not junk; it benefits those whose bodies produce low amounts of it. As a testosterone-booster, though, it’s effective only for women.
Plants don’t actually contain real testosterone but rather plant sterols. The human body lacks the enzymes required to convert plant sterols into true steroids, although it can be done in a lab. That explains why plant sterols were—and in some cases still are—used to produce steroid drugs. One plant known to contain an actual androgen—the truffle—is a type of mushroom. Truffles naturally contain a very weak androgen called androst-16-en-3-ol. It isn’t very anabolic, which explains why you don’t see any mushrooms competing for the Mr. Olympia title.
Perhaps the foremost herbal testosterone booster is Tribulus terrestris, which grows wild in Bulgaria and elsewhere. Tribulus contains various plant sterols, including diosgenin. Most of the sterols are categorized as saponins, since they produce a soaplike effect when metabolized. The active anabolic ingredient in tribulus is a saponin called protodioscin.
Purveyors of tribulus often note that if it doesn’t contain enough protodioscin, it’s useless for building muscle, although it does have other properties, including diuretic effects and coronary artery dilation. Normally tribulus contains about 5 percent protodioscin. One study analyzed commercial tribulus supplements for their protodioscin content. It varied, with samples from Bulgarian sources having more and those from China and India the least. Quality control is a real problem with tribulus, as it is with many other herbal supplements.
Tribulus came to the attention of Western athletes after poorly controlled Russian research revealed that it increased testosterone. The initial studies involved animals, such as rams. In the human studies that followed, tribulus was given to men with clinically low testosterone levels. One study found that men receiving 750 milligrams of tribulus daily for five days showed a 72 percent increase in luteinizing hormone, along with a 40 percent rise in testosterone. Less publicized was the accompanying 81 percent rise in estrogen.
Luteinizing hormone is produced in the pituitary gland and governs the production of testosterone in the testes. It’s suggested that tribulus contains a substance called harmine that blunts the breakdown of an enzyme in the brain that degrades dopamine. Elevated dopamine encourages the production of not only luteinizing hormone and subsequent testosterone but also growth hormone. The much touted “active” tribulus ingredient, protodioscin, aids DHEA synthesis and release.
Based on these mechanisms, tribulus should indeed be an efficient testosterone booster, although increasing DHEA wouldn’t have much of an anabolic effect in young men. Animal studies seem to confirm the hormone-boosting effect of tribulus. One recent study, in which primates, rats and rabbits were given a tribulus extract intravenously, resulted in a 52 percent increase in testosterone, a 31 percent rise in the testosterone metabolite DHT and a 29 percent rise in DHEA-S in the primates. The rats in the study were castrated but still experienced a 51 percent rise in testosterone. Rabbits didn’t fare as well, showing mainly a 32 percent increase in undesirable DHT.1 Another study showed that giving rats tribulus protected against diabetes through antioxidant activity.2
Animal studies can’t always be extrapolated to humans. While the research on tribulus emanating from Russia is nothing short of glowing, the herb hasn’t fared as well under Western scientific scrutiny. One study involved 15 men who got either a placebo or tribulus at a dose of 3.21 milligrams per kilogram of bodyweight daily. The subjects followed an eight-week weight-training routine. Muscle endurance increased on the bench press and leg press in the placebo group, while those in the tribulus group showed an increase only in leg press strength. No changes in body composition occurred in either group.3
Another study examined the effects of either a placebo or 450 milligrams a day of tribulus in 22 rugby players who were engaged in weight training for five weeks. Both groups produced similar gains, along with no rise in testosterone in the tribulus group.4Still another study looked at whether tribulus raises testosterone in young men. The 21 subjects took either tribulus or a placebo for four weeks. Tribulus had no effect.5
Given that tribulus can raise estrogen, it’s not surprising that there’s at least one case study on record of a young bodybuilder who acquired gynecomastia, or male breast formation, after using a tribulus supplement.6 DHEA can easily convert into estrogen, particularly in younger men, although it more often converts into a metabolite of DHT.
One company is selling what it calls a “potent testosterone booster” based on the herb fenugreek. According to the company’s claims, substances in fenugreek called fenusides promote a significant rise in free, or active, testosterone. The company mentions a study in which 55 men, aged 18 to 35, all actively involved in weight training, were divided into two groups, with 29 receiving the fenugreek product and 26 getting a placebo. The subjects were evaluated three times over the eight-week course of the study. Those in the fenugreek group showed a 100 percent rise in free testosterone compared to the placebo group, along with a reduction in skin folds, pointing to lowered bodyfat.
Sounds impressive, until you realize that this was an unpublished study done by the company making the product. No other details of the experiment were mentioned. Interestingly, fenugreek contains some of the same plant sterols found in tribulus, including protodioscin, as well as diosgenin, which was as found in Mexican yams. It contains a unique amino acid called 4-hydroxyisoleucine that has an effect similar to insulin in aiding glucose uptake. One study of cyclists showed that fenugreek seemed to increase the efficiency of muscle glycogen repletion when taken with glucose, which is precisely what insulin does.
I’ll have more on testosterone boosters next month.
References
2 Lotfy, A.A., et al. (2006). The protective effect of tribulus terrestris in diabetes. Ann NY Acad Sci. 1084:391-401.
3 Antonio, J., et al. (2000). The effects of tribulus terrestris on body composition and exercise performance in resistance-trained males. Int J Sport Nutr Exerc Metab. 10:208-15.
4 Rogerson, S., et al. (2007). The effect of five weeks of tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players. J Str Cond Res. 21:348-53.
5 Neychev, V.K., et al. (2005). The aphrodisiac herb tribulus does not influence the androgen production in young men. J Ethnopharmacol. 101:319-23.
6 Jameel, J.K., et al. (2004). Gynecomastia and the plant product “tribulus terrestris.”Breast. 13:428-30.
All Natural Testosterone Booster 742 Potency Tonic, Muscle Building for Male and Female. Made in USA
SPECIAL OFFERS All Natural Testosterone Booster 742 Potency Tonic, Muscle Building for Male and Female. Made in USA
Price : $18.32* (on 7/31/2013)
Code : B00DEKTP3G
Rating : 
* Special discount only for limited time
* Product prices and availability are accurate as of the indicated date / time and can be changed any time. Any price and availability on this website at the time of purchase will apply to the purchase of this product.
Specification
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Product Details
- Amazon Sales Rank: #47195 in Health and Beauty
- Brand: Sports Nutrition & Vitamins
- Dimensions: 3.00" h x
2.00" w x
2.00" l,
.38 pounds
Features
- 1 Month Supply of Natural Testosterone Booster, our formula now available in tablets
- Each capsule contains the precise amount of testosterone boosting ingredients
- Can Help Build Lean Muscle Mass - Gain Clarity of Mind and Boost Energy
- Noticeable Increases in Energy, Libido, Recovery and Mood Within 2-4 Weeks
- Made In USA - FDA & cGMP Certified Facilities
Product Description
Testosterone Booster 742 contains the most potent and biologically active ingredients created by the original researchers at the University Malaya and MIT to increase Free Testosterone(FT) and unbind bound testosterone. Testosterone Booster 742 ingredients have studies published in the British Journal of Sports Medicine, The Journal of International Society of Sports Medicine and the International Journal of Andrology and Asian Journal of Andrology.
Most Customers Report Results Within 2-3 Weeks
- Natural and Safe Ingredients
- Dramatic increases in energy and Libido
- Noticeable reduction of fat in mid section
- Long Lasting 6 Week Supply
- Improves muscle recovery time
- Increased mental focus and clarity
Testosterone Booster 742 unbinds Bound Testosterone(BT) and improves Free Testosterone(FT) without increase in aromatization into estrogen. Testosterone Booster 742 proprietary blend signals the hypothalamus and pituitary glands to naturally enhance your own testosterone levels. This product will not shut down natural testosterone producing capabilities after stopping use.
Sex Hormone Binding Globulin(SHBG) binds a high percentage of testosterone to fat cells making it inactive. When testosterone is bound, it becomes unable for use in the body. Free Testosterone is responsible for providing the body with energy, mood enhancement, increasing and maintaining muscle mass and enhancing sex drive. Testosterone Booster 742 improves Free Testosterone bio availability and aids in decreasing levels of SHBG.
OUR GUARANTEE
- Made in USA
- 60 Day No Questions Money Back Guarantee
- FDA & cGMP Certified Facilities
- 100% Pure and Natural Ingredients
Most Customers Report Results Within 2-3 Weeks
- Natural and Safe Ingredients
- Dramatic increases in energy and Libido
- Noticeable reduction of fat in mid section
- Long Lasting 6 Week Supply
- Improves muscle recovery time
- Increased mental focus and clarity
Testosterone Booster 742 unbinds Bound Testosterone(BT) and improves Free Testosterone(FT) without increase in aromatization into estrogen. Testosterone Booster 742 proprietary blend signals the hypothalamus and pituitary glands to naturally enhance your own testosterone levels. This product will not shut down natural testosterone producing capabilities after stopping use.
Sex Hormone Binding Globulin(SHBG) binds a high percentage of testosterone to fat cells making it inactive. When testosterone is bound, it becomes unable for use in the body. Free Testosterone is responsible for providing the body with energy, mood enhancement, increasing and maintaining muscle mass and enhancing sex drive. Testosterone Booster 742 improves Free Testosterone bio availability and aids in decreasing levels of SHBG.
OUR GUARANTEE
- Made in USA
- 60 Day No Questions Money Back Guarantee
- FDA & cGMP Certified Facilities
- 100% Pure and Natural Ingredients
Customer Reviews
Most helpful customer reviews
1 of 1 people found the following review helpful.
highly recommended!
By Customer
Great value and after 3 weeks of use I'm seeing a significant difference, my muscles have never looked so toned and defined. Product arrived quickly and hassle-free. I will definitely be ordering more soon.
highly recommended!By Customer
Great value and after 3 weeks of use I'm seeing a significant difference, my muscles have never looked so toned and defined. Product arrived quickly and hassle-free. I will definitely be ordering more soon.
1 of 1 people found the following review helpful.
Best test booster i ever used!
By Luke
Best test booster ever... Tried a few others before and seems like there was little to no results... been taking for almost 2 weeks and love it... my energy levels are up and i feel energized all thru the day. Very good product and a very good price.
Best test booster i ever used!By Luke
Best test booster ever... Tried a few others before and seems like there was little to no results... been taking for almost 2 weeks and love it... my energy levels are up and i feel energized all thru the day. Very good product and a very good price.
1 of 1 people found the following review helpful.
All Natural Test Booster
By Gabe Polishuk
Excellent product. Easy to use and no side effects. Key ingredients compared to similar products from other various brands. Great price point.
See all 3 customer reviews...All Natural Test BoosterBy Gabe Polishuk
Excellent product. Easy to use and no side effects. Key ingredients compared to similar products from other various brands. Great price point.
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